Self-Powered Systems (SPSs) targeting the Internet-of-Things (IoT) have the potential to monitor an incredible array of environments and equipment, providing previously unavailable rich data and insights [1]. Unlike battery-powered systems that optimize for energy per operation, SPSs must scale their power consumption in response to environmental changes. This presents both a challenge and an opportunity for such systems: 1) they must have a low power floor to continuously operate at low harvested power (low $\mathrm{P}_{\mathrm{H}})$ , but 2) they also can scale up their performance when harvesting conditions are favorable (high $\mathrm{P}_{\mathrm{H}})$ . Many existing IoT SoCs and platforms have a power floor that is too high [2] or are too low performance [3]. We propose an SoC for SPSs that pushes the power floor down to $2.19\mu\mathrm{W}$ , simultaneously harvests from multiple sources, cold starts from low $\mathrm{P}_{\mathrm{H}}(60\text{Lux},\ 8^{\mathrm{o}}\mathrm{C})$ , scales system performance based on environmental conditions, and improves the wakeup receiver sensitivity to −92dBm, all while allowing the system to maintain a small form factor enabling data collection even in the most challenging environments without the use of a battery. With these features, the proposed SoC can take advantage of the near infinite energy available to SPSs to do far more work than can be done with battery-powered systems.

PURPOSE:To describe the natural history, management, and visual outcome in children with congenital primary aphakia (CPA).METHODS:This is a multicenter retrospective consecutive case series from five academic centers in England and North America.RESULTS:A total of 27 eyes of 14 patients were included (male:female, 1.7:1). Thirteen patients had bilateral CPA, and 1 patient had unilateral CPA. Mean age at diagnosis was 18 months (median, 21; range, 0.5-144). Of 11 patients who underwent genetic testing, 9 had FOXE3 pathogenic variants. In all patients, visual acuity at presentation was not better than fixing and following light. Typical findings included silvery appearance of the cornea with vascularization (96%), glaucoma (81%), iridocorneal adhesions (74%), optic nerve coloboma (55%), abnormal vitreous (33%), retinal detachment (30%), and aniridia with hypoplasia of ciliary body (19%). Surgical interventions in select patients included penetrating keratoplasty (PKP), glaucoma drainage device implantation, and cyclophotocoagulation (CPC).CONCLUSIONS:Eyes with corneal ectasia and a silvery appearance of the cornea with vascularization should alert the physician to the possibility of CPA. Glaucoma causes globe enlargement and may increase the risk of corneal perforation, but glaucoma is often refractory to medical treatment, and the threshold for surgical treatment should be low. PKP outcomes are very poor.

This paper presents a system-on-chip (SoC) that enables commercial self-powered systems (SPSs) by flexibly managing application needs, harvesting energy from multiple modalities, coordinating low-latency/high-density network communication, and optimizing power across the system. To scale to a trillion IoT nodes, devices must untether from batteries by achieving energy autonomy. A SPS must balance harvested power $(\mathrm{P}_{\mathrm{H}})$ with load power $(\mathrm{P}_{\mathrm{L}})$ to enable continuous operation, which becomes challenging in real-world harvesting conditions for applications with stringent functional needs. While this SoC can support many IoT applications, we demonstrate the SoC in a machine health monitoring (MHM) product that uses multi-modal sensors to forecast motor failure to minimize downtime.

As an African American male working in public health, the author has few peers in the field who can related to his experiences from a gender and race standpoint, and even fewer in his work as a doula and lactation educator. His work and experiences as a trail blazer in this field have involved a lot of emotional labor, but have been a blessing and a joy as well as providing him with a unique lens into the world of birth work and how nuances at the intersection of gender and race affect his peers.

mutations in the FOXE3 gene(s) in ⊠ diagnostic, ⊠ predictive and ⊠ prenatal settings and for ⊠ risk assessment in relatives.

This article reports the findings of a 3-year study of a hybrid professional development program designed to prepare science and mathematics teachers to implement GIS in their classrooms. The study was conducted as part of the CoastLines Innovative Technology Experiences for Students and Teachers project funded by the National Science Foundation. Three cohorts of teachers participated in the program, with each participant receiving 40 h of synchronous online instruction and 80 h of in-person instruction and support over an 8-month period. Data from surveys of participants both before and after the program were analyzed using correlation, ordinary least squares, and ordered logit regression analyses. The analyses revealed increases in the self-reported frequency of GIS use and enhanced feelings of preparation, competence, community, and comfort with respect to using GIS for instruction. A composite index of all impact variables was positively influenced as well. The statistical analyses found a strong relationship between self-reported feelings of preparation and use of GIS. Some support was found for the idea that feelings of competence, community, and comfort were related to the teachers' sense of preparation. The findings suggest that a robust hybrid model of teacher professional development can prepare teachers to use GIS in their classrooms. More research is needed to understand how hybrid models influence the sociopsychological and other dimensions that support teachers' feelings of preparation to implement GIS.

...................................................................................................................... ii ACKNOWLEDGMENTS ................................................................................................. ii