The hemodynamic effects of a decreasing plasma urea level during hemodialysis were studied in acutely uremic, conscious dogs. Each dog was studied twice, during dialytic ultrafiltration against both a urea-free (U-) and a urea-supplemented (U+) dialysate. Plasma osmolality (-13 mosm/kg/H2O +/- 10 SD, p less than 0.01) and urea levels (-43 mg/dl +/- 20, p less than 0.01) decreased when using the (U-) dialysate, but were unchanged with the (U+) dialysate. At the end-point of volume depletion (MAP less than 80 mm Hg) total peripheral resistance index [U (+): 3,376 +/- 743 dyn . s X cm-5 X m2, U(-): 3,091 +/- 537, NS)] and blood volume [U(+): 62.7 +/- 7.4 ml/kg, U(-): 63.7 +/- 7.5, NS)] were comparable whether or not the plasma urea level had been allowed to decrease. The data suggest that an acutely decreasing plasma urea level during dialysis does not impair hemodynamic response to volume depletion in the model described.

Hemodynamic response to volume depletion by isolated ultrafiltration was compared in uremic (U) and nonuremic (N) conscious dogs. Fluid was removed at a constant rate until mean arterial pressure (MAP) decreased to less than 80 mmHg. Initial MAP was higher in the uremic dogs [132 +/- 8.6 (SD) mmHg] than in nonuremic controls (106 +/- 12, P less than 0.001). Initial cardiac index [U 4.97 +/- 0.831 X min-1 X m-2, N 4.44 +/- 0.62] and total peripheral vascular resistance index [(TPRI) U 2,160 +/- 353 dyn X s X cm-5 X m-2, N 1,976 +/- 420] were slightly, but not significantly, higher in uremic animals. Initial central venous pressure, wedge pressure, and plasma norepinephrine level were greater in the uremic dogs. At the end point of volume depletion, both uremic and nonuremic animals had achieved similar levels of TPRI, despite greatly attenuated or absent increases in plasma renin activity in the uremic group. At end point, blood volumes and plasma norepinephrine levels were comparable. The increase in pulse rate was higher in the uremic animals (59 +/- 37 pulses/min) compared with controls (25 +/- 52, P less than 0.05). In an additional group of uremic dogs, cardiovascular responses to hemorrhage and isolated ultrafiltration were compared and found to be similar, after allowance for blood viscosity changes had been made. The data suggest that in acutely uremic conscious dogs, despite reduced renin-angiotensin responses, hemodynamic adaptation to rapid volume depletion is not impaired.

Artificial OrgansVolume 4, Issue 2 p. 130-131 Feedback Regulation of Ultrafiltration Rate During Hemodialysis John T. Daugirdas, John T. Daugirdas Veterans Administration Hospital, Hines, Illinois, U.S.A.Search for more papers by this authorTodd S. Ing M.D, Todd S. Ing M.D Veterans Administration Hospital, Hines, Illinois, U.S.A. Veterans Administration Hospital, Hines, Illinois 60141, U.S.A.Search for more papers by this authorWei-Tzuoh Chen, Wei-Tzuoh Chen Veterans Administration Hospital, Hines, Illinois, U.S.A.Search for more papers by this author John T. Daugirdas, John T. Daugirdas Veterans Administration Hospital, Hines, Illinois, U.S.A.Search for more papers by this authorTodd S. Ing M.D, Todd S. Ing M.D Veterans Administration Hospital, Hines, Illinois, U.S.A. Veterans Administration Hospital, Hines, Illinois 60141, U.S.A.Search for more papers by this authorWei-Tzuoh Chen, Wei-Tzuoh Chen Veterans Administration Hospital, Hines, Illinois, U.S.A.Search for more papers by this author First published: May 1980 https://doi.org/10.1111/j.1525-1594.1980.tb03919.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume4, Issue2May 1980Pages 130-131 RelatedInformation

Artificial OrgansVolume 3, Issue 4 p. 377-379 A Method of Delivering Dialysate of Constantly Decreasing Osmolality During Dialysis W. T. Chen, W. T. Chen Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorT. S. Ing, Corresponding Author T. S. Ing Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.AVeterans Administration Hospital. Hines, Illinois 60141. U.S.ASearch for more papers by this authorJ. T. Daugirdas, J. T. Daugirdas Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorD. J. Brescia, D. J. Brescia Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorH. Humayun, H. Humayun Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorV. C. Gandhi, V. C. Gandhi Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorJ. E. Huno, J. E. Huno Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorM. J. Quon, M. J. Quon Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this author W. T. Chen, W. T. Chen Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorT. S. Ing, Corresponding Author T. S. Ing Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.AVeterans Administration Hospital. Hines, Illinois 60141. U.S.ASearch for more papers by this authorJ. T. Daugirdas, J. T. Daugirdas Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorD. J. Brescia, D. J. Brescia Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorH. Humayun, H. Humayun Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorV. C. Gandhi, V. C. Gandhi Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorJ. E. Huno, J. E. Huno Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorM. J. Quon, M. J. Quon Departments of Medicine, Veterans Administration Hospital, Hines, Illinois, U.S.A. and Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this author First published: November 1979 https://doi.org/10.1111/j.1525-1594.1979.tb01082.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume3, Issue4November 1979Pages 377-379 RelatedInformation

The effect of negative-pressure isolated ultrafiltration on leucocytes, platelets, and clotting factors was evaluated in maintenance hemodialysis patients. A significant decrease in the number of leucocytes was observed during the first 45 minutes of ultrafiltration. However, by one hour, leucocyte counts had returned to pre-ultrafiltration values. A slight, of haptoglobin, free hemoglobin, or fibrinogen after one hour of isolated ultrafiltration. Levels of fibrin degradation products and fibrin monomers similarly showed no change. Heparin administration alone had no effect on the above hematologic values. We suggest that isolated ultrafiltration, as clinically practised, has little acute effect on the coagulation system, and does not cause detectable hemolysis. The transient decrease in leucocyte count, and the modest fall in platelet count that were found are in keeping with changes previously reported to occur during hemodialysis.

Artificial OrgansVolume 3, Issue 2 p. 185-188 The Old and the New in Ultrafiltration Techniques Todd S. Ing, Corresponding Author Todd S. Ing Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Veterans Administration Medical Center, Hines, Illinois, 60141, U.S.ASearch for more papers by this authorWei-Tzuoh Chen, Wei-Tzuoh Chen Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Search for more papers by this authorJohn T. Daugirdas, John T. Daugirdas Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Search for more papers by this authorW. Peter Geis, W. Peter Geis Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorJessie E. Hano, Jessie E. Hano Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this author Todd S. Ing, Corresponding Author Todd S. Ing Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Veterans Administration Medical Center, Hines, Illinois, 60141, U.S.ASearch for more papers by this authorWei-Tzuoh Chen, Wei-Tzuoh Chen Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Search for more papers by this authorJohn T. Daugirdas, John T. Daugirdas Departments of Medicine and Surgery, Veterans Administration Medical Center, Hines, Illinois, U.S.A.Search for more papers by this authorW. Peter Geis, W. Peter Geis Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this authorJessie E. Hano, Jessie E. Hano Loyola University Stritch School of Medicine, Maywood, Illinois, U.S.ASearch for more papers by this author First published: May 1979 https://doi.org/10.1111/j.1525-1594.1979.tb01036.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume3, Issue2May 1979Pages 185-188 RelatedInformation

Artificial OrgansVolume 2, Issue 2 p. 203-205 In Search of “Psoriasis Factor(s)“: A New Approach by Extracorporeal Treatment Wei-Tzuoh Chen, Wei-Tzuoh Chen Department of Hypertension and Nephrology, The Cleveland Clinic FoundationSearch for more papers by this authorChung H. Hu, Chung H. Hu Division of Dermatology, University Hospitals, Case Western Reserve University, Cleveland, Ohio, 44106.Search for more papers by this authorJohn R. Schiltz, John R. Schiltz Division of Dermatology, University Hospitals, Case Western Reserve University, Cleveland, Ohio, 44106.Search for more papers by this authorSatoru Nakamoto, Satoru Nakamoto Department of Hypertension and Nephrology, The Cleveland Clinic FoundationSearch for more papers by this author Wei-Tzuoh Chen, Wei-Tzuoh Chen Department of Hypertension and Nephrology, The Cleveland Clinic FoundationSearch for more papers by this authorChung H. Hu, Chung H. Hu Division of Dermatology, University Hospitals, Case Western Reserve University, Cleveland, Ohio, 44106.Search for more papers by this authorJohn R. Schiltz, John R. Schiltz Division of Dermatology, University Hospitals, Case Western Reserve University, Cleveland, Ohio, 44106.Search for more papers by this authorSatoru Nakamoto, Satoru Nakamoto Department of Hypertension and Nephrology, The Cleveland Clinic FoundationSearch for more papers by this author First published: May 1978 https://doi.org/10.1111/j.1525-1594.1978.tb03452.xCitations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Farber, E. M., Pearlman, D., Abel, E. A. An appraisal of current systemic chemotherapy for psoriasis. Arch Dermatol, 112: 1679, 1976. 10.1001/archderm.1976.01630360047013 CASPubMedWeb of Science®Google Scholar 2 Parrish, J. A. Photochemotherapy of psoriasis. Arch Dermatol, 112: 35, 1976. CASPubMedWeb of Science®Google Scholar 3 McEvoy, J., Kelly, A. M. T. Psoriatic clearance during hemodialysis. Ulster Med J, 45: 76, 1976. CASPubMedGoogle Scholar 4 Twardowski, Z. J. Abatement of psoriasis and repeated dialysis. Ann Intern Med, 85: 509, 1977. 10.7326/0003-4819-86-4-509_2 Google Scholar 5 Nosé, Y. Is the “artificial kidney“ only a kidney? Artif Organs, 2: 1, 1978. 10.1111/j.1525-1594.1978.tb00994.x PubMedWeb of Science®Google Scholar 6 Buselmeier, T. J., Dahl, M. V., Burgdorf, W. H. C., Goltz, R. W. Remission of psoriasis with dialysis treatment. Abst Soc for Invest Derm Central Regional Meeting, 1978. Google Scholar 7 Voorhees, J. J., Marcelo, C. Molecular mechanisms and the cyclic nucleotide cascade in psoriasis. Proc 2nd Int Psoriasis Symp, p. 91, 1976. Google Scholar 8 Beutner, E. H., Chorzelski, T. P., Jablonska, S. Autoimmunity in psoriasis. Proc 2nd Int Psoriasis Symp, p. 63, 1976. Google Scholar 9 Cormane. R. H., Hunyadi, J., Hamerlinck, F. The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis. Proc 2nd Int Psoriasis Symp, p. 47, 1976. Google Scholar 10 Gelfant, S. The cell cycle in psoriasis: a reappraisal. Brit J Derm, 95: 577, 1976. 10.1111/j.1365-2133.1976.tb07028.x CASPubMedWeb of Science®Google Scholar 11 Weinstein, G. D., Van Scott, E. J. Autoradiographic analysis of turnover times of normal and psoriatic epidermis. J Invest Dermatol, 45: 257, 1965. 10.1038/jid.1965.126 CASPubMedWeb of Science®Google Scholar 12 Schiltz, J. R., Michel, B. Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum. J Invest Dermatol, 67: 254, 1976. 10.1111/1523-1747.ep12513454 PubMedWeb of Science®Google Scholar 13 Reaven, E. P., Cox, A. J. Organ culture of human skin. J Invest Dermatol, 44: 151, 1965. PubMedWeb of Science®Google Scholar 14 Bohrer, M. P., Baylis, C., Humes, H. D., Glassock, R. J., Robertson, C. R., Brenner, B. M. Permselectivity of the glomerular capillary wall. J Clin Invest, 61: 72, 1978. 10.1172/JCI108927 CASPubMedWeb of Science®Google Scholar 15 Proctor, M. S., Fletcher, H. V., Shukla, J. B., Rennekt, O. M. Elevated spermidine and spermine levels in the blood of psoriasis patients. J Invest Dermatol, 65: 409, 1975. 10.1111/1523-1747.ep12607659 CASPubMedWeb of Science®Google Scholar Citing Literature Volume2, Issue2May 1978Pages 203-205 ReferencesRelatedInformation

Peritoneal dialysis using a chloride-rich dialysate succeeded in correcting systemic metabolic alkalosis in a patient with renal failure. The present approach may have a place in the therapy of metabolic alkalosis.