目的:探讨苏子降气汤联合喜炎平治疗对痰浊壅肺型慢性阻塞性肺疾病(COPD)急性发作期患者肺功能的影响.方法:将106 例痰浊壅肺型COPD急性发作期患者作为研究对象,按照治疗方案不同分为对照组(n =53)和观察组(n = 53).对照组采用喜炎平治疗;观察组在对照组的基础上采用苏子降气汤治疗.比较两组患者临床疗效、肺功能相关指标、炎症因子水平、中医证候积分及圣乔治呼吸问卷(SGRQ)评分.结果:治疗后,观察组总有效率高于对照组(P＜0.05),肺功能各指标均高于对照组(P＜0.05),炎性因子水平、中医证候积分各维度评分及SGRQ评分均低于对照组(P＜0.05).结论:苏子降气汤联合喜炎平治疗痰浊壅肺型COPD急性发作期患者具有明显的临床效果,可改善患者的肺功能及中医证候积分,降低炎性因子水平,提高患者生命质量.

目的 探讨丹参酮ⅡA磺酸钠注射液(ST-ⅡA-S)治疗老年急性冠状动脉综合征(Acute coronary syndrome,ACS)患者的临床疗效及作用机制.方法 选取2017年7月—2020年6月期间在北京市第一中西医结合医院就诊的118例老年ACS患者为研究对象,采用随机数字表法分为观察组和对照组,每组各59例.对照组予以常规治疗,观察组在常规治疗基础上加用ST-ⅡA-S治疗.两组患者均治疗2周后,比较两组患者治疗前后炎症因子[超敏C反应蛋白(High sensitive C-reactive protein,hs-CRP)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)],氧化应激指标[基质金属蛋白酶-9(Matrix metalloprotei-nase-9,MMP-9)、同型半胱氨酸(Homocysteine,Hcy)、脂质过氧化物(Lipid Peroxidation,LPO)、丙二醛(Malondial-dehyde,MDA)、超氧化物歧化酶(Superoxide dismutase,SOD)],免疫指标[免疫球蛋白IgA(Immunoglobin A,IgA)、IgG(Immunoglobin G,IgG)、IgM(Immunoglobin M,IgM)]及心肌损伤标志物[N末端脑钠肽前体(N-terminal pro-brain nitric peptide,NT-proBNP)、肌钙蛋白I(Troponin I,TnI)]水平变化,并评估临床疗效及安全性.结果 治疗后观察组总有效率93.22％(55/59)明显优于对照组79.66％(47/59),差异有统计学意义(P<0.05).两组患者治疗后hs-CRP、TNF-α、IL-6、MMP-9、Hcy、LPO、MDA、IgA、IgG、IgM、NT-proBNP、TnI水平均较治疗前下降,SOD水平较治疗前升高,差异有统计学意义(P<0.05);且观察组hs-CRP、TNF-α、IL-6、MMP-9、Hcy、LPO、MDA、IgA、IgG、IgM、NT-proBNP、TnI指标水平均较对照组明显下降,SOD水平较对照组明显升高,差异有统计学意义(P<0.05).治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05).结论 ST-ⅡA-S能减轻老年ACS患者炎症及氧化应激反应,改善免疫功能,下调心肌损伤标志物水平,临床效果较好,安全性高.

一、什么样的人会出现气道梗阻? 首先是婴幼儿,因为会厌软骨发育不成熟,功能不健全,在玩耍、哭闹或者吸食时容易将嘴里的东西吸入气管内引起窒息.容易引起气道梗阻的有花生、瓜子、果冻、硬币、纽扣、笔帽、鸡骨头等等,所以尽量不要给孩子吃或者玩上述物品.

Objective:To observe the effect of Jiuni Decoction on left heart function and quality of life in patients with acute myocardial infarction.Methods:110 patients were randomly divided into two groups.The control group was treated with routine treatment and interventional therapy.The observation group was treated with Jiuni Decoction on the basis of the control group,and the differences of left heart function,quality of life and TCM syndrome scores were compared between the two groups before and after treatment.Results:After treatment,LVEDVI,LVESVI,LVDd,and LVDs of both groups were significantly lower than before treatment and improvement in observation group were better than control group.After treatment,IVSd,LVPWd,LVEF,and LVMI of both groups were significantly lower than before treatment and obvious improvement was observed in the observation group compared with the control group (P＜ 0.05).After treatmeut,the dimensions of quality of life were significandy improved,and in the observation group and the total scores of physiological function,body pain,general health,mental health,health changes,improved significantly compared with the control group (P ＜ 0.05).After treatment,the TCM syndrome scores were significantly lower than those before treatment,and the observation group improved significantly compared with the control group (P＜0.05).Conclusion:Jiuni Decoction can improve the left heart function and increase the quality of life in patients with heart-blood stasis type acute myocardial infarction.

Objective To investigate the therapeutic effect of cinepazide maleate on patients with acute myocardial infarction and the effect on the hs-CRP and IL-6 level.Methods Retrospective analysis of clinical data of patients with acute myocardial infarction from August 2014 to May 2016 in the hospital, according to the treatment methods, they were divided into cinepazide treatment group and conventional treatment group.The therapeutic effect of two groups were observed, and the differences of inflammatory factors,heart rate variability and cardiac function were compared between the two groups before and after treatment.Results The clinical effective rate of cinepazide treatment group was 96.9%, which was significantly higher than that of the conventional treatment group 87.1%(X2=4.528,P=0.033);Before treatment, the levels of IL-6 and hs-CRP were not significantly different between the 2 groups (t=0.738,t=-0.132,P=0.231,P=0.448);after treatment, the cinepazide treatment group was lower than the conventional treatment group (t=7.706,t=8.291,P<0.01);Two groups of patients before treatment of heart rate variability levels have no significant difference (P>0.05),after treatment, the cinepazide treatment group's SDNN, SDANN, RMSSD and PNN50 (%) were higher than the control group (t=-6.299,t=-4.657,t=-7.744,t=-6.947,P<0.01);before treatment the level of SV, NT-proBNP,CTnI,SV and LVEF levels were had no significant differences between the 2 groups (t=0.036,t=0.687,t=0.057,t=0.085,P>0.05);after treatment, the cinepazide treatment group's SV and LVEF were higher than the control group (t=-5.992,t=-5.940,P<0.01), NT-proBNP, CTnI in the cinepazide treatment were lower than the conventional treatment group (t=57.370,t=17.407,P<0.01).Two groups of patients during the treatment showed no adverse reactions such as liver and kidney damage.Conclusion Cinepazide has better therapeutic effect on patients with acute myocardial infarction, it can significantly improve cardiac function and reduce hs-CRP and IL-6 level.