Based on computed tomography (CT) data and histological analysis, a biomimetic modeling is established that mimics the interior configuration of natural bone to provide bionic three-dimension (3D) model of the artificial bone, thus obtaining processing files for fabrication. In this study, porosity ratio and process route of the microarchitecture in the modeling are analysed. Furthermore, through the simulation experiment, it shows that the biomimetic modeling can simulate the fidelity of the interior osteo-structure analogous microarchitecture.