We present the case of a 9-month-old boy with yellow-brown papules that gradually increased in number over a period of 6 months without systemic involvement. Our case was clinicopathologically diagnosed as S-100-positive juvenile xanthogranuloma, and longitudinal observation revealed that strong S-100 reactivity disappeared in parallel with maturation of the lesions within 2 years after the initial diagnosis. These findings add to the complexity in cells of origin of this disorder.

ABSTRACTA 69‐year‐old woman presented with a 2‐year history of an eczematous lesion covering the genital area. Histopathological examination showed deposits of amorphous, eosinophilic material and an infiltrate of plasma cells through the entire dermis into the subcutaneous fatty tissue. Congo red‐stained deposits showed apple‐green birefringence with polarizing microscopy. On immunohistochemistry, the deposited material was positively stained with anti‐κ light chain antibodies but not with anti‐λ light chain. A diagnosis of primary localized cutaneous amyloidosis (PLCA) was made, and the patient was also diagnosed as having Sjögren's syndrome (SjS) based on clinical and laboratory findings. The lesion of PLCA has spontaneously regressed over a period of 18 months. We report a unique case of PLCA and SjS that clinically demonstrated genital eczematous features and spontaneous involution, and we also describe a possible association between PLCA and SjS.

Letters| April 27 2007 Photosensitivity Might Be Associated with Drug-Induced Hypersensitivity Syndrome Subject Area: Dermatology , Immunology and Allergy Youichi Nishimura Youichi Nishimura Department of Dermatology, Fukui Red Cross Hospital, Fukui, Japan Search for other works by this author on: This Site PubMed Google Scholar Dermatology (2007) 214 (4): 338–339. https://doi.org/10.1159/000100887 Article history Published Online: April 27 2007 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Youichi Nishimura; Photosensitivity Might Be Associated with Drug-Induced Hypersensitivity Syndrome. Dermatology 1 April 2007; 214 (4): 338–339. https://doi.org/10.1159/000100887 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsDermatology Search Advanced Search Keywords: Photosensitivity, Drug-induced hypersensitivity syndrome, Drug rash with eosinophilia and symptoms, Viral reactivation This content is only available via PDF. © 2006 S. Karger AG, Basel2007Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.

Dear Editor, Confluent and reticulated papillomatosis (CRP), first described by Gougerot and Carteaud in 1927,1 is a relatively rare dermatosis that is clinically characterized by persistent, hyperkeratotic, reticulated and pigmented macules usually observed on the upper trunk and neck. It has been reported that CRP may be treated with minocycline, etretinate or a topical vitamin D3 analogue. We describe a case of maxacalcitol-resistant CRP successfully treated with minocycline. A 44-year-old woman was admitted to our hospital with a 20-year history of a non-pruritic, hyperpigmented eruption. Her past medical history was unremarkable, and her family history was negative for similar lesions. Physical examinations demonstrated obesity and hyperpigmented keratotic macules with a reticular pattern on the neck, shoulders and sternal region (Fig. 1). Histopathological examinations revealed epidermal orthohyperkeratosis, pigmentation in the basal layer and papillomatosis without a fungal element (Fig. 2). A potassium hydroxide preparation was negative for Pityrosporum orbiculare. No endocrinological disorders were detected. These findings were clinicopathologically consistent with the diagnosis of CRP, and treatment with a topical vitamin D3 analogue (maxacalcitol ointment) was started, but there was no response after 3 months. Then treatment was started with oral minocycline (100 mg/day). The skin lesion completely resolved in approximately 1 month (Fig. 3). There has been no recurrence. The etiology of CRP remains unclear, but there have been a variety of suggested hypotheses, such as an association with a keratinization defect,

Drug-induced hypersensitivity syndrome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus-6 (HHV-6) reactivation. We present a case of clomipramine-induced hypersensitivity syndrome, which displayed in succession two different reactions akin to those described for Gianotti-Crosti syndrome and infectious mononucleosis. HHV-6 reactivation was confirmed serologically after the latter reaction, suggesting that our case may have represented a biphasic reaction to HHV-6 reactivation.

The Journal of DermatologyVolume 31, Issue 9 p. 769-770 Letter to the Editor A Case of Eperisone Hydrochloride-Induced Acute Generalized Exanthematous Pustulosis Yosuke Yamamoto, Corresponding Author Yosuke Yamamoto Department of Dermatology, Toyooka Hospital, Toyooka, Japan Correspondence to: Yosuke Yamamoto Department of Dermatology, Toyooka Hospital 6-35, Tachino-cho, Toyooka Hyogo 668-8501, JapanSearch for more papers by this authorMasafumi Kadota, Masafumi Kadota Department of Dermatology, Toyooka Hospital, Toyooka, JapanSearch for more papers by this authorYouichi Nishimura, Youichi Nishimura Department of Dermatology, Toyooka Hospital, Toyooka, JapanSearch for more papers by this author Yosuke Yamamoto, Corresponding Author Yosuke Yamamoto Department of Dermatology, Toyooka Hospital, Toyooka, Japan Correspondence to: Yosuke Yamamoto Department of Dermatology, Toyooka Hospital 6-35, Tachino-cho, Toyooka Hyogo 668-8501, JapanSearch for more papers by this authorMasafumi Kadota, Masafumi Kadota Department of Dermatology, Toyooka Hospital, Toyooka, JapanSearch for more papers by this authorYouichi Nishimura, Youichi Nishimura Department of Dermatology, Toyooka Hospital, Toyooka, JapanSearch for more papers by this author First published: 22 July 2014 https://doi.org/10.1111/j.1346-8138.2004.tb00595.xCitations: 6Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume31, Issue9September 2004Pages 769-770 RelatedInformation

The present paper reports a case of restless legs syndrome (RLS) in which the Flowtron DVT (Huntleigh Technologies, Luton, UK) was used as a deep vein thrombosis prevention system. The patient was a 31-year-old man who had experienced RLS since he was 28 years of age. Polysomnography was performed on the patient and the sleep patterns before and after the use of the Flowtron DVT were compared. After the treatment, the International Restless Legs Syndrome Study Group rating scale of severe (30 points) was improved to mild (10 points) and the sleep patterns of the patient were almost normal, with both RLS and insomnia greatly diminished.

Multiple Bowen's disease may be difficult to differentiate from bowenoid papulosis because of its clinicopathological resemblance to bowenoid papulosis. We experienced a case of bilaterally and symmetrically developed multiple bowenoid lesions in a 71-year-old man previously diagnosed as having chronic lymphocytic lymphoma (CLL). Based on histological findings and the results of human papillomavirus examinations, we finally diagnosed this case as bilateral Bowen's disease. We speculate that the underlying immunosuppressive state due to CLL may have been associated with onset of the disease. We report the unique clinical picture, the differential diagnosis and the aetiology.

Chemotherapy-induced acral erythema (CIAE) is a rare cutaneous reaction to high-dose chemotherapy, clinically featuring painful erythema on the palms and soles. Docetaxel (Taxotere), an anticancer agent, is known to cause various reactions, including CIAE. We experienced a case of docetaxel-induced acral erythema with facial edematous erythema that coincidentally emerged and regressed with appearance and disappearance of the acral lesions. Docetaxel-induced acral erythema exhibits a widespread distribution and intense sensations of intolerable pain and numbness. Therefore, some authors use the term erythrodysesthesia instead of acral erythema. We speculated that the facial erythema might be part of the spectrum of erythrodysesthesia. Our case was finally diagnosed as decetaxel-induced erythrodysesthesia. Although CIAE is self-limiting, the patients frequently require treatment because of intolerable pain. Reported treatments for CIAE include topical or systemic steroids, elevation of the legs, and application of cold compression to the lesion. In our case, application of a steroid ointment with the occlusive dressing technique (ODT) alleviated the clinical manifestations and was also prophylactic for the erythrodysesthesia.

The Journal of DermatologyVolume 31, Issue 8 p. 699-700 Letter to the Editor Ligation Therapy for Pyogenic Granuloma Youichi Nishimura, Corresponding Author Youichi Nishimura Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 Japan Correspondence to: Youichi Nishimura Ishi-jutaku 9, 9-2, Saiwai-cho Toyooka, Hyogo 668-0025, JapanSearch for more papers by this authorYosuke Yamamoto, Yosuke Yamamoto Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 JapanSearch for more papers by this authorMasafumi Kadota, Masafumi Kadota Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 JapanSearch for more papers by this author Youichi Nishimura, Corresponding Author Youichi Nishimura Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 Japan Correspondence to: Youichi Nishimura Ishi-jutaku 9, 9-2, Saiwai-cho Toyooka, Hyogo 668-0025, JapanSearch for more papers by this authorYosuke Yamamoto, Yosuke Yamamoto Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 JapanSearch for more papers by this authorMasafumi Kadota, Masafumi Kadota Department of Dermatology, Toyooka Hospital, Tachino-cho 6-35, Toyooka, Hyogo, 668-8501 JapanSearch for more papers by this author First published: 22 July 2014 https://doi.org/10.1111/j.1346-8138.2004.tb00582.xCitations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Patrice SJ, Wiss K, Mulliken JB: Pyogenic granuloma (lobular capillary hemangioma): A clinicopathologic study of 178 cases, Pediatr Dermatol, 8: 267–276, 1991. 2Jackson AD: Cryosurgery: A guide for GPs, Practitioner, 243: 131–136, 1999. 3Holbe HC, Frosch PJ, Herbst RA: Surgical pearl: ligation of the base of pyogenic granuloma—An atraumatic, simple, and cost-effective procedure, J Am Acad Dermatol, 49: 509–510, 2003. 4Lotan G, Klin B, Efrati Y: Double-ligature: a treatment for pedunculated umbilical granulomas in children, Am Fam Physician, 65: 2067–2068, 2002. 5Rayan GM, Frey B: Ulnar polydactyly, Plast Reconstr Surg, 107: 1449–1454, 2001. 6Fazio VW, Tjandra JJ: The management of perianal diseases, Adv Surg, 29: 59–78, 1996. 7Pontecorvo C, Pesce G: The ‘safety snare’ —A ligature-placing snare to prevent haemorrhage after transection of large pedunculated polyps, Endoscopy, 18: 55–56, 1986. Citing Literature Volume31, Issue8August 2004Pages 699-700 ReferencesRelatedInformation

A 65-year-old woman suddenly developed a widespread sterile pustular outbreak with high pyrexia. Many pustules appeared on her hands, including both the dorsal and the palmer side, and a few pustule appeared on her trunk and arms in the pattern of acute generalized pustular bacterid. Histopathology of the eruption showed subcorneal pustules. The eruption and pyrexia did not resolve with any of several antibiotics and NSAIDs, but resolved with the oral etretinate. Thereafter, pustules and scaly erythema remained on the arch of the foot and thenar of the palm, typical of pustulosis palmaris et plantaris.

Videotaping was conducted at home, in cooperation with patients' mothers. The recorded sounds were then analyzed. Compared with snoring sounds obtained via polysomnography, representative cases that demonstrate the usefulness of videotaping at home were presented. The subjects were eight children who received polysomnography, recording the snoring at our department during the 1-year period, from March 2002 to February 2003. The snoring recording was conducted using polysomnography. As for the taping method, the sounds from the microphone were taken into an acoustic analysis system II (TDT) and recorded on an MD, using a ZS-M75 (SONY). As for the method of analysis, the MD-recorded snore sounds were analyzed using Time Frequency Representation (TFR) (Avaaz Innovation), an acoustic analysis software program for Windows. The snoring sounds recorded by home video camera as well as those obtained by polysomnography were analyzed. The snoring sounds obtained via polysomnography and by the home video camera contained noise components on sound spectrograms and showed waves in which the basic frequency changed. It thought that the noise made by the adenoids and the hypertrophy of palatine tonsil were not the cause of snoring, but rather that the vibration of the soft palate and the uvula participated in pediatric snoring. (C) 2003 Elsevier B.V. All rights reserved.

The following six parameters were studied in 119 patients who responded to a questionnairebased long-term survey of 208 adults who had undergone surgery for obstructive sleep apnea syndrome in the previous 8 years: 1) snoring, 2) sleep apnea, 3) daytime sleepiness, 4) nocturnal arousal, 5) malaise, and 6) quality of sleep.The patients were divided into a markedly or moderately improved group (group A) and a slightly improved or unchanged group (group B) based on improvement of the apnea-hypopnea index (AHI) after surgery.In group A, improvement of snoring, sleep apnea, daytime sleepiness, and quality of sleep tended to decrease over the long term.In group B, improvement of these four symptoms was more marked than improvement of the AHI in the early postoperative period (1 year after surgery), with a significant difference between the two. The same pattern was also apparent in the long-term results.There was no major difference between the improvement of nocturnal awakening or malaise and improvement of the AHI over either the short or long term in groups A or B.

High precision A/F electronic control, which is an application of modern control technology, has played a special role as a ULEV emissions reduction technology. Observer theory has been used to compensate for variations in the air/fuel ratio between cylinders, and self tuning regulators have been used to control transient conditions and disturbances. These innovations have led to improvements in control performance.

The principal target nuclei of nigrothalamic projections in the rat are the mediodorsal (MD) and ventromedial (VM) nuclei. The present study examined the patterns of distribution and collateral projections of the two major groups of nigrothalamic neurons, i.e., nigro-MD and nigro-VM neurons. Retrograde fluorescent labeling with Fluoro-Gold was used to examine whether the distribution areas of nigro-MD and nigro-VM neurons might be overlapped with or segregated from each other in the substantia nigra pars reticulata. A clear tendency was observed that nigro-MD neurons were distributed more ventrally than nigro-VM neurons. It was further examined by retrograde fluorescent double labeling with Fluoro-Gold and Fluoro-Ruby whether or not these nigrothalamic neurons might provide axon collaterals to the superior colliculus or the pontine reticular formation. The nigro-MD neurons were found to send axon collaterals to the superior colliculus more frequently than the nigro-VM neurons. Additionally, a small number of nigrothalamic neurons were found to send axon collaterals to the pontine reticular formation. The functional significance of the two major populations of nigrothalamic neurons was discussed on the basis of their collateral projections to the superior colliculus or the pontine reticular formation.

In a conventional fuel metering control system (speed density method) for an internal combustion engine, the fuel injection amount during transient operation is usually determined by using mapped data and various settings in a feedforward system predetermined through experimentation. However, this still does not necessarily represent the ideal level of compensation under a diverse range of environmental conditions. In order to satisfy various demanding requirements, such as reducing emissions, it is vital that the controllability of the air excess ratio ({lambda}) be enhanced. The main technological obstacle that needs to be overcome is how best to determine accurately the required fuel amount from the engine in the feedforward system. To enable accurate prediction of the cylinder intake air volume, physical formulas of fluid dynamics were used to facilitate formulation of a model for the dynamic behavior of the intake air. In order to allow real-time calculation, an extremely simple yet highly accurate injection fuel amount calculation was used, in which certain elements are combined with the conventional speed density method. This enabled the controllability {lambda} to be dramatically enhanced. In addition, the number of transient fuel compensation items were substantially reduced.