We present an ultrafast laser surgery probe for bone tissue microsurgery. A custom miniaturized CaF2 mitigated the strong multiphoton absorption observed in our previous ZnS-based design while providing tighter beam focusing over a larger ablation field-of-view. The objective produced a beam waist radius of 1.71 μm covering a 130×130 μm2 scan area, delivering fluences >8 J/cm2 at the tissue surface at 53% transmission efficiency. The entire opto-mechanical system, enclosed within a 14 mm diameter metal housing with a 2.6 mm probe tip, exhibited material removal rates >0.1 mm3/min in bovine cortical bone. We performed simulations when using a high-power fiber laser and found that material removal rates >40 mm3/min could be achieved through selection of optimal laser surgery parameters. The device can serve as a clinically viable solution for minimally invasive spinal surgery applications.

We present a miniaturized ultrafast laser surgery probe with improved miniaturized optics to deliver higher peak powers and enable higher surgical speeds than previously possible. A custom-built miniaturized CaF 2 objective showed no evidence of the strong multiphoton absorption observed in our previous ZnS-based probe, enabling higher laser power delivery to the tissue surface for ablation. A Kagome fiber delivered ultrashort pulses from a high repetition rate fiber laser to the objective, producing a focal beam radius of 1.96 μm and covering a 90×90 μm 2 scan area. The probe delivered the maximum available fiber laser power, providing fluences >6 J/cm 2 at the tissue surface at 53% transmission efficiency. We characterized the probe’s performance through a parametric ablation study on bovine cortical bone and defined optimal operating parameters for surgery using an experimental- and simulation-based approach. The entire opto-mechanical system, enclosed within a 5-mm diameter housing with a 2.6-mm diameter probe tip, achieved material removal rates >0.1 mm 3 /min, however removal rates were ultimately limited by the available laser power. Towards a next generation surgery probe, we simulated maximum material removal rates when using a higher power fiber laser and found that removal rates >2 mm 3 /min could be attained through appropriate selection of laser surgery parameters. With future development, the device presented here can serve as a precise surgical tool with clinically viable speeds for delicate applications such as spinal decompression surgeries.

We present a fiber-based snapshot imaging spectrometer capable of imaging in VIS and NIR spectral windows. The system's principle is based on the application of a custom imaging fiber bundle to re-organize the input vs. output of the fiber structure. While, the input consists of densely populated fibers, the output provides void spaces between the fibers to accommodate spectral information and non-scanning datacube acquisition. Recently, we presented a proof of concept paper demonstrating the general system's capabilities [1]. The prototype, however, experienced significant light loss while still providing good imaging performance. This paper focuses on the throughput analysis and improvement of the light collection efficiency. We were able to define configurations that improve throughput by over 10+ fold and enable integration times below 1 ms. Here, we briefly describe the system's principle, discuss re-imaging configurations, and present examples of imaging results.

A fiber-based snapshot imaging spectrometer was developed with a maximum of 31853 (~188 x 170) spatial sampling and 61 spectral channels in the 450nm-750nm range. A compact, custom-fabricated fiber bundle was used to sample the object image at the input and create void spaces between rows at the output for dispersion. The bundle was built using multicore 6x6 fiber block ribbons. To avoid overlap between the cores in the direction of dispersion, we selected a subset of cores using two alternative approaches; a lenslet array and a photomask. To calibrate the >30000 spatial samples of the system, a rapid spatial calibration method was developed based on phase-shifting interferometry (PSI). System crosstalk and spectral resolution were also characterized. Preliminary hyperspectral imaging results of the Rice University campus landscape, obtained with the spectrometer, are presented to demonstrate the system's spectral imaging capability for distant scenes. The spectrum of different plant species with different health conditions, obtained with the spectrometer, was in accordance with reference instrument measurements. We also imaged Houston traffic to demonstrate the system's snapshot hyperspectral imaging capability. Potential applications of the system include terrestrial monitoring, land use, air pollution, water resources, and lightning spectroscopy. The fiber-based system design potentially allows tuning between spatial and spectral sampling to meet specific imaging requirements.

Imaging techniques e.g. field slicing and mapping, fiber field arrays to rapidly acquire multi-dimensional data are discussed. They allow recording and display of spectral, polarization and in general 3D+ information in a snapshot mode.

A 3D printing technique for manufacturing air-clad coherent fiber optic faceplates is presented. The custom G-code programming is implemented on a fused deposition modeling (FDM) desktop printer to additively draw optical fibers using high-transparency thermoplastic filaments. The 3D printed faceplate consists of 20000 fibers and achieves spatial resolution 1.78 LP/mm. Transmission loss and crosstalk are characterized and compared among the faceplates printed from four kinds of transparent filaments as well as different faceplate thicknesses. The printing temperature is verified by testing the transmission of the faceplates printed under different temperatures. Compared with the conventional stack-and-draw fabrication, the FDM 3D printing technique simplifies the fabrication procedure. The ability to draw fibers with arbitrary organization, structure and overall shape provides additional degree of freedom to opto-mechanical design. Our results indicate a promising capability of 3D printing as the manufacturing technology for fiber optical devices.

A prototype fiber-based imaging spectrometer was developed to provide snapshot hyperspectral imaging tuned for biomedical applications. The system is designed for imaging in the visible spectral range from 400 to 700 nm for compatibility with molecular imaging applications as well as satellite and remote sensing. An 81 × 96 pixel spatial sampling density is achieved by using a custom-made fiber-optic bundle. The design considerations and fabrication aspects of the fiber bundle and imaging spectrometer are described in detail. Through the custom fiber bundle, the image of a scene of interest is collected and divided into discrete spatial groups, with spaces generated in between groups for spectral dispersion. This reorganized image is scaled down by an image taper for compatibility with following optical elements, dispersed by a prism, and is finally acquired by a CCD camera. To obtain an (x, y, λ) datacube from the snapshot measurement, a spectral calibration algorithm is executed for reconstruction of the spatial-spectral signatures of the observed scene. System characterization of throughput, resolution, and crosstalk was performed. Preliminary results illustrating changes in oxygen-saturation in an occluded human finger are presented to demonstrate the system's capabilities.

We present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel for fast tissue microsurgery. Delivery of micro-Joules level energies to the tissue was made possible by a large, 31 μm, air-cored inhibited-coupling Kagome fiber. We overcome the fiber's low NA by using lenses made of high refractive index ZnS, which produced an optimal focusing condition with 0.23 NA objective. The optical design achieved a focused laser spot size of 4.5 μm diameter covering a 75 × 75 μm2 scan area in a miniaturized setting. The probe could deliver the maximum available laser power, achieving an average fluence of 7.8 J/cm2 on the tissue surface at 62% transmission efficiency. Such fluences could produce uninterrupted, 40 μm deep cuts at translational speeds of up to 5 mm/s along the tissue. We predicted that the best combination of speed and coverage exists at 8 mm/s for our conditions. The onset of nonlinear absorption in ZnS, however, limited the probe's energy delivery capabilities to 1.4 μJ for linear operation at 1.5 picosecond pulse-widths of our fiber laser. Alternatives like broadband CaF2 crystals should mitigate such nonlinear limiting behavior. Improved opto-mechanical design and appropriate material selection should allow substantially higher fluence delivery and propel such Kagome fiber-based scalpels towards clinical translation.

A miniature laser ablation probe relying on an optical fiber to deliver light requires a high coupling efficiency objective with sufficient magnification in order to provide adequate power and field for surgery. A diffraction-limited optical design is presented that utilizes high refractive index zinc sulfide to meet specifications while reducing the miniature objective down to two lenses. The design has a hypercentric conjugate plane on the fiber side and is telecentric on the tissue end. Two versions of the objective were built on a diamond lathe-a traditional cylindrical design and a custom-tapered mount. Both received an antireflective coating. The objectives performed as designed in terms of observable resolution and field of view as measured by imaging a 1951 USAF resolution target. The slanted edge technique was used to find Strehl ratios of 0.75 and 0.78, respectively, indicating nearly diffraction-limited performance. Finally, preliminary ablation experiments indicated threshold fluence of gold film was comparable to similar reported probes.

We present the development of a 5 mm, piezo-actuated, ultrafast laser scalpel that delivers upwards of 1 μJ at the target surface. Experiments show fast and effective surface ablation of tissue tens of microns deep.

We report a method to promote photoluminescence emission in graphene materials by enhancing carrier scattering instead of directly modifying band structure in multilayer reduced graphene oxide (rGO) nanospheres. We intentionally curl graphene layers to form nanospheres by reducing graphene oxide with spherical polymer templates to manipulate the carrier scattering. These nanospheres produce hot-carrier luminescence with more than ten-fold improvement of emission efficiency as compared to planar nanosheets. With increasing excitation power, hot-carrier luminescence from nanospheres exhibits abnormal spectral redshift with dynamic feature associated to the strengthened electron-phonon coupling. These experimental results can be well understood by considering the screened Coulomb interactions. With increasing carrier density, the reduced screening effect promotes carrier scattering which enhances hot-carrier emission from such multilayer rGO nanospheres. This carrier-scattering scenario is further confirmed by pump-probe measurements.

Femtosecond pump-probe spectroscopy is applied to identify transient optical signatures of phase transitions in nearly optimally doped YBa2Cu3O7-delta films. To elucidate the dynamics of superconducting and pseudogap phases, the slow thermal component is removed from the timedomain traces of photo-induced reflectivity in a high-flux regime with low frequency pulse rate. The rescaled data exhibit distinct signatures of the phase separation with abrupt changes at the onsets of T-SC and T-PG in excellent agreement with the transport data. Compared to the superconducting phase, the response of the pseudogap phase is characterized by the strongly reduced reflectivity change accompanied by a faster recovery time. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4793012]

AbstractA new visible (VIS; 0.55–0.9 μm) albedo normalization method, that is, the quasi-Lambertian surface adjustment (QLSA), is developed herein by using the geostationary meteorological satellite data and radiative transfer model. Taking the variation of relative locations between the sun, satellite, and clouds into account, the QLSA effectively reduces the inconsistencies in the VIS image brightness caused by the Lambertian surface approximation to cloud tops (i.e., the reflection characteristic is isotropic). The evaluation, using Chinese and Japanese geostationary satellite data, shows that the QLSA is more effective and accurate than three other albedo normalization methods currently in use. The new algorithm is applicable in regions with solar zenith angle and satellite zenith angle less than 60°, which, in the summertime, approximately corresponds to the time range from 0800 to 1600 local time (LT).