Objective To study effects of rhizoma dioscoreae hypoglaucae on the uric acid elimination. Methods 70 mice were randomly divided into 7 groups: normal control,model control,benzbromarone group,high and low dose of water extract and ethanol extract of Dioscorea collettii Hook.Var,respectively,10 in each group.Mice in normal control and model group were orally treated with 0.02 mL·g-1 N.S.,others were i.g.benzbromarone 0.03 g·kg-1,water extracts 10 and 20 g·kg-1,and ethanol extract of Dioscorea collettii Hook.Var 10 and 20 g·kg-1,respectively.Mice were treated once at 8:00 and 16:00 every day,for five consecutive days.Except for normal control group,others were i.p.injected with monosodium urate suspension 0.025 mL·g-1 after the last treatment to induce hyperuricemia.The blood samples were collected from eye balls at different time after the model construction,and isolated the serum to detect uric acid by uric acid analysis regent kits. Results It was shown that the high dose of water extract significantly reduced the uric acid in the serum of both rats and mice,which similar to benzbromarone. Conclusion Rhizoma Dioscoreae Hypoglaucae exhibits anti-gout function.

Aim: To study anti-inflammatory and analgesic effects of aqueous extracts of dioscorea collettii var by foot swollen experiment in mice and rats induced by sodium urate and mice pain experiment due to hot bath. Methods: This experiment was conducted at the Xi'an Taiming Insti tute for Pharmacology from October 2002 to May 2003. The foot swollen experiment included 40 mice and 40 rats, and the animals were assigned randomly into 4 groups, respectively. They were perfused with saline with the same volume, 0.13 g/kg indomethacin suspension, doses of 10 g/ kg and 20 g/kg aqueous extracts of dioscorea collettii var, respectively. Hindfoots of the right side of mice and rats were injected with sodium urate suspension inducing inflammation. The diameter of talocrural joint of inflammatories anklebones was measured at 0.5, 1, 2, 3, 4 and 6 hours. Forty analgesic mice were divided randomly, and the groups and administration were the same to foot swollen experiment. The tails of the mice were put into homeothermia bath with 45 °C temperature at 1 and 2 hours after the last administration, and note the time of mice pushing tail as the pained threshold. Results: 1 Inhibitiv e effects of aqueous extracts of dioscorea collettii var on foot swelling in mice and rats: Dose of 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var could decrease significantly the foot swelling in mice after inflammation of mice for 3 or 4 hours, and its effects was the same to indomethacin [it was (0.602±0.138), (0.373±0.099), (0.421±0.187), (0.409±0.177) mm at 3 hours in the saline group, indomethacin group and 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var group, respectively; (0.530±0.135), (0.325±0.125), (0.349 ±0.124), (0.317±0.110)mm,P < 0.05 or 0.01 at 4 hours, respectively]. After inflammation for 3 hours in rats, the foot swelling was decreased significantly [It was (1.148±0.214), (0.660±0.368), (0.760±0.494), (0.745 ±0.404)mm,P < 0.05 or P < 0.01 in the saline group, indomethacin group and 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var group, respectively]. 2 Effects of aqueous extracts of dioscorea collettii var on pain due to hot bath in mice: Dose of 20 g/kg of aqueous extracts of dioscorea collettii var could obviously prolong the time of rebounding tails in mice due to hot bath, enhance threshold value, and its analgesic effects was equal to that in the indomethacin group [Pain threshold value was (8.19±2.83), (14.68±4.58), (12.90±4.85)s,P < 0.05 or P < 0.01, respectively in the saline group, indomethacin group and 20 g/kg aqueous extracts of dioscorea collettii var group]. Conclusion: Th e aqueous extracts of dioscorea collettii var can decrease remarkably the foot swelling in mice and rats, heighten pain threshold value in mice and have certain effects on gouty arthritis induced by sodium urate.

目的:研究阿昔洛韦片的相对生物利用度.方法:采用标准二阶段交叉设计自身对照试验方法,应用反相高效液相色谱法测定20名健康自愿受试者单剂量口服400 mg阿昔洛韦片后,阿昔洛韦血药浓度变化情况,经3p97药动学程序处理.结果:药-时曲线下面积分别为(4.67±1.01) (μg·h)/L和(4.67±1.19) (μg·h)/L,达峰时间分别为(1.80±0.48) h和(1.75±0.49) h,峰浓度分别为(1.13±0.13)μg/L与(1.12±0.18)μg/L.配对t检验与双单侧t检验结果表明,二者药-时曲线下面积、峰浓度及达峰时间均无显着性差异(P>0.05).阿昔洛韦片供试品的相对生物利用度为101.3%.结论:阿昔洛韦片供试品与标准参比制剂为生物等效制剂.

本文综述了黄杨宁对心脏肌力和频率、血管、血压、抗心肌缺血和抗心律失常等药理作用.

OBJECTIVE:To prepare famotidine sodium chloride injection METHODS:The famotidine sodium chloride injection was prepared with aspartic acid as solutizing agent and sodium chloride injection as solvent The contents of famotidine and its related substances were determined by means of HPLC Influencing factor and the stability of famotidine were studied and the therapeutic effect was observed RESULTS:The content of famotidine was slowly reduced while temperature rising and time prolongine The content of famotidine was 98 6% at the end of the 6th month at 40℃ with accelerating experiment Its content was 98 4% after one year storage under room temperature Its content was 98 5% at the 10th day after illumination with 4 500Lx light in accelerating experiment The content of related substances was less than 2% The total effective rate was 93 75% CONCLUSION:Famotidine sodium chloride injection was stable in property and had definite therapeutic effect,and its clinical application was simple and free from contamination

用反相高效液相色谱法测定软膏中替硝唑的含量,采用Shim-packCLC-ODS柱,流动相为甲醇-水(20:80),紫外检测波长317nm,平均回收率为99.2%,RSD为1.81%.

目的:本文的研究为临床用药和配制替硝唑(TNZ)外用药选择适宜药物浓度和促进剂浓度提供依据.方法:观察TNZ对小白鼠离体皮肤的透皮吸收,比较不同药物浓度的透皮吸收量及月桂氮(艹卓)酮(Azone)不同浓度的促渗作用.结果:0.2%,0.4%,1.0% TNZ,12 h透皮吸收量分别为1.41,2.82,7.12mg·(50 ml)-1,渗透系数分别为12.98×10-6,13.68×10-6,13.77×10-6.促渗剂Azone含量在5%以下时,TNZ透皮吸收百分率随着Azone浓度的提高而增加;当Azone含量达8%时,透皮吸收率反而下降.结论:TNZ可透过离体小白鼠皮肤,提高药物浓度可增加药物的透皮吸收量.促渗剂Azone用量以2%～5%为最佳.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">ＮＭＤＡ导致神经细胞释放ＬＤＨ及其预防陈世虎赵润鼎陈淑萍毛幼桦（陕西省人民医院药物研究室，西安７１００６８）中国图书分类号Ｒ９７１Ｎ－甲基－Ｄ－天门冬氨酸（ＮＭＤＡ）受体是中枢神经系统中兴奋性氨基酸谷氨酸离子型受体，被认为参与了象亨延顿病、癫痫、帕金...</span>