Loss of mitochondrial integrity can promote T cell exhaustion through proteasome-mediated release of regulatory haem.

Intestinal macrophages that support the enteric nervous system may be involved in the spread of α-synuclein pathology from the gut to the brain.

CD8+ T cells infiltrating the kidneys contribute to lupus nephritis by retaining cytotoxic functions despite appearing to be terminally differentiated.

Serum albumin binds and prevents the oxidation of free fatty acids, which then prevent the expression of virulence factors in Mucorales fungi.

Androgens support IL-10-expressing monocytes that alleviate inflammatory pain.

Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.

Neutrophils not only kill invading microorganisms but also help to prevent their entry into tissues in the first place.

Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus.

Respiratory infections in early life combine with genetic and maternal factors to drive asthma development in childhood.

Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses.

Maternal obesity during pregnancy promotes a form of fatty liver disease in offspring that is dependent on HIF1α-mediated rewiring of Kupffer cell metabolism.

Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus for cardiovascular disease.

Two new studies describe populations of neurons in distinct brain regions that respond to IL-17 family cytokines and IL-10 to regulate social and anxiety-like behaviours.

Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.

Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL-5 and IL-10.

A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN signalling.

A population of interferon-stimulated neutrophils can predict the success of immunotherapy outcomes in various cancers.

The pyroptotic secretome can be beneficial in promoting tissue repair.

Commensal bacteria induce liver macrophages that protect the tissue against inflammation.

Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven apoptosis.