The increasing patients' requirements for high quality service are contradicted to the limited human resources in many famous hospitals of China. How to provide satisfactory services for patients is deeply concerned by more and more hospitals. This paper presents an integrated solution of digital signage application in the outpatient building of hospitals to improve patients' treatment efficiency. A survey was conducted on five Third-level grade-A hospitals in Beijing. Two forms were included in this survey: distribution of questionnaires to patients and site investigation. Then problems of digital signage application and treatment procedure were concluded through analysis of the results of the survey. Information requirements in four locations were analyzed and each of these four places was provided a solution to meet patients' needs. In order to share information provided by digital signage, Radio Frequency Identification technology was applied in this paper to facilitate patients' treatment. This new integrated solution of digital signage application in the outpatient building in hospitals emphasizes on patients needs, which make digital signage products can be fully utilized.

This paper presents the preliminary statistical results of the latest national anthropometric survey of the minors in China mainland. About 20,000 minors (9666 males and 9699 females) were recruited from six geographical areas in China. These subjects were divided into five age groups. Body weight plus totally 134 static dimensions were selected for measurement. Non-contact three-dimensional (3D) scanning technology was used in this survey while manual measuring and two-dimensional (2D) imaging measurement were used as the subsidiary methods. There is no significant difference on body height between genders at the significance level of 0.05 when the subjects are less than 12 years old. The 5th, 50th and 95th percentile values for nineteen selected dimensions were addressed. This work provides the first national wide anthropometric database of the minors in China mainland and will inevitable benefit the products design for the potential users.

The purpose of this study is to develop sizing systems for Chinese minors. This work is based on the most up-to-date and complete national-wide anthropometric survey in China mainland. About 20,000 minors (9666 males and 9699 females) were recruited from six geographical areas in China. Body weight plus totally 134 static dimensions were collected. Stature, the bust waist girth difference (BWGD) and bust girth were finally identified through factor analysis as the three most critical parameters out of thirteen frequently used anthropometric dimensions in sizing systems. Three sizing systems were established systematically by stature group and gender, i.e., both genders shorter than 130 cm, male minors taller than 130 cm and female minors taller than 130 cm. The accommodation rate of the developed sizing systems is 47.23%, 60.19% and 81.87%, respectively. The number of sizes in each system is 25, 25 and 19, respectively. The results provide valuable references for the garment manikin design related with Chinese minors.

(BALB/cxSJL)F1 mice, perinatally injected with peptide-N-glyconase F-treated, deglycosylated IgE heavy chain or recombinant IgE heavy chain (CH epsilon 2-CH epsilon 4), were profoundly inhibited in antigen-specific IgE production. There exist minimally two tolerogenic IgE peptides, residing in the CH epsilon 2 and CH epsilon 4 domains. Peptide I, generated by V8 protease, comprises 39 amino acids within CH epsilon 2, beginning at amino acid 103. Peptide E begins at amino acid 312 of the CH epsilon 4 domain and extends through the CH epsilon 4 domain. The total lack of antigen-specific IgE responses in IgE peptide-treated mice was not due to overproduction of interferon-gamma, nor lack of interleukin (IL)-4, as predicted by the Th2/IL-4 paradigm for IgE production. IgE-tolerant mice exhibited comparable levels of circulating from sera of both sources failed to inhibit IgE responses in vitro. Moreover, IgE responses of spleen cells from IgE peptides-treated mice were restored by CD4(+) T cells from PBS-treated control mice. We hypothesize that regulation of antigen-specific IgE responses is mediated by CD4(-) T cells which normally recognize IgE peptides on IgE precursor B cells, and can be rendered tolerant by perinatal IgE peptide treatment.

CD23+ B cell hybridoma 17A11, pulsed with IgE:TNP-KLH triggered IgA, IgG, and IgE antibody production via CD23-mediated presentation. Prior anti-CD23 treatment abrogated 95% of the humoral antibody responses. Both B and T cell epitopes were presented by 17A11 B cell epitopes as recognized by IgG but not T cell epitopes were sensitive to treatment with 0.2 M acetic acid. Efficacy of antigen presentation via CD23 on 17A11 was comparable to that mediated via surface immunoglobulins (sIg) on a CD23 negative 4.5 parental fusion partner B cell line. This is the first demonstration that IgE:TNP-KLH pulsed B cell hybridomas present both B- and T-cell epitopes in stimulating IgA, IgG, and IgE antibody production, and raise a pertinent issue whether IgE antibodies produced under pathophysiological conditions may serve as positive feedback signal for sustaining production of different classes of antibodies.

The mammary gland is of cutaneous origin with stromal leucocytic infiltrates and it excretes leucocytes in the milk. Milk T lymphocytes are highly enriched by sedimenting milk somatic cells in a 43 per cent preformed Percoll gradient. Thirty to 54 per cent of leucocytes, harvested from the upper Percoll band, belong to CD2+ CD3+ T lymphocytes. These milk T lymphocytes are mature CD4+, or CD8+ single positive T cells, expressing CD44, CD26, and beta 1 integrin, but not Lam-1. Milk T lymphocyte subsets may play an important role in regional immunosurveillance of the mammary epithelia and stroma. Selective mechanisms may account for the trafficking of this activated, memory T lymphocyte subset in the gland.

The membrane IgE peptide (MEP) encompassing 20 amino acids proximal to the C terminus of membrane IgE molecules, and secretory IgE peptides (SEP), spanning CH epsilon 1 to 4 domain were synthesized according to IgE genomic and cDNA sequences. Inhibition of anti-KLH and anti-BGG IgE, but not IgG responses was observed in mice treated with MEP-protein but not SEP-protein conjugates in complete/incomplete Freund's adjuvant. Only IgE responses directed toward proteins to which MEP was conjugated, were inhibited, while IgE responses to a concomitantly injected, unrelated antigen were not. Inhibition of antigen-specific IgE was also not correlated with levels of anti-MEP or anti-IgE antibodies, moreover, levels of total IgE remained comparable among mice treated with MEP-protein conjugates, native or glutaraldehyde-modified protein carriers. This observation may have significant import on future design of IgE immunotherapy. Treatment of MEP conjugated allergens prevents formation of IgE-anti-IgE complexes because the MEP sequence is absent from the secretory IgE.