目的 应用数据挖掘和聚类分析总结刘松江治疗乳腺癌学术思想和辨证思路.方法 将患者基本信息、四诊、诊断及治疗等病历信息录入中国中医科学院提供的中医传承辅助平台(V3.0),建立刘松江治疗乳腺癌的医案数据库.并以此数据库为基础,运用关联规则分析、改进的互信息法、复杂系统熵聚类等方法进行数据统计和分析.结果 通过对98首处方,194味药物的功效统计,使用频次最多的为补虚药,通过关联规则分析常用药对及置信度得到核心处方,利用聚类分析得到4个类方.结论 总结刘松江治疗乳腺癌调理阴阳,以"和"为贵,重视整体兼顾局部的学术思想.

伏邪理论雏形最早出现于《黄帝内经》,至今为止对许多疾病的诊疗仍具有重大的意义.近年来我国结肠癌发病率不断升高,且发病年龄趋于年轻化,严重危及人们的生命健康.文章以伏邪理论探讨结肠癌的发病机制,认为伏邪致病与现代医学中溃疡性结肠炎相关结肠癌的发病机制极为相似,均是潜伏的致病因素,且缠绵反复伤害机体正气最终爆发致病.溃疡性结肠炎便是溃疡性结肠炎相关结肠癌病程中的伏邪,加之其腹泻、脓血便等症状表现,可归为湿热伏邪,以此为基础进行理论探讨,可能为结肠癌疾病的预防、治疗、防复发及转移开拓新思路.

目的:应用数据挖掘方法分析和总结刘松江教授治疗乳癌病的用药经验和学术思想.方法:利用中国中医科学院提供的中医传承辅助平台(V2.5),录入患者基本信息、四诊、诊断及治疗等病历信息,建立刘松江教授治疗乳腺癌的医案数据库.并以此数据库为基础,运用关联规则分析、改进的互信息法、复杂系统熵聚类等方法进行数据统计和分析.结果:统计频次分析刘松江教授使用药物规律:药物四气统计表明使用最多的是温性药和平性药;药物五味统计表明使用最多的是甘味药和苦味药;药物归经统计表明使用最多的是肝经、脾经和肺经;药物使用频次最多的为茯苓、夏枯草、白术、甘草、黄芪、鸡内金、柴胡、山楂、太子参、鸡血藤.以改进的互信息法的药物间关联度分析结果为基础,得到11首新处方.结论:刘松江教授治疗乳癌病中重视调理阴阳,以"和"为贵,兼顾脾胃,并将"治未病"思想融入肿瘤防治的各个阶段.

Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. As a widely used complementary and alternative therapy, acupuncture is increasingly used to treat PCOS. However, the effect of acupuncture in treating PCOS is uncertain, and the mechanisms are unclear. This systematic review aims to determine the efficacy of acupuncture on PCOS in animal preclinical models. Methods. Experimental animal studies of acupuncture in PCOS animal models were searched in PubMed, Web of Science, China National Knowledge Infrastructure, and the Chinese Science and Technology Periodical Database from inception to December 2020. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool. Results. A total of 358 studies were screened based on the title and abstract, and 31 studies were included. A total of 722 animals were involved, and all studies used either Wistar rats or SD rats. Twenty-six studies used electroacupuncture, 9 studies used manual acupuncture, and 5 of them employed both electroacupuncture and manual acupuncture. A total of 22 acupoints were involved; 7 studies followed the modern acupuncture pattern, and the rest followed classic acupuncture theory. Conclusions. The present review summarizes the current evidence of the effects of acupuncture on PCOS in animal models. Unfortunately, we could not draw a definite conclusion due to the methodological weakness of the included studies and the high heterogeneity. Well-designed studies are needed in the future to fill this gap.