This study shows that genomic DNA in the cytoplasm can transfer between mammalian cells through nanotube-like structures, integrate into the genome of recipient cells and support gene expression.
H3.14, a histone variant of unknown role, has a dual transcriptional function in the abiotic stress response in plants: activation of stress response genes and inhibition of growth genes.
Target-directed miRNA degradation through interaction with non-coding parts of mRNAs is required for proper mammalian development.
Nucleosomes — the basic unit of chromatin architecture — have intrinsic biophysical features of large-scale genome organization.
Independently of its nuclear DNA-binding activity, the transcription factor PXR has a cytoplasmic function: it binds to mRNAs and promotes their stability.
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.
Sites of N6-methyladenosine (m6A) in the coding region of mRNAs can induce a distinct, translation-dependent decay pathway involving mRNA translocation to P-bodies.
Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby supporting the maintenance of the long-lived oocytes.
Stresses induce de-crowding and fluidization of the cytoplasm, which promotes the formation of biomolecular condensates.
Early zebrafish embryos increase the size and complexity of their nuclear pore complexes, enabling efficient nuclear import of maternal transcription factors, which induces zygotic genome activation.
Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.
Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.
Subunits of the SWI/SNF chromatin remodelling complexes 'bookmark' cell-type specifying genes during mitosis to allow their timely reactivation upon mitosis exit.
In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.
During cellular stresses, the mRNA internal 7-methylguanosine (m 7 G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.
Cold temperature prolongs lifespan in nematodes by inducing ubiquitin-independent proteasome activity, which prevents protein aggregation and neuronal degeneration. The pathway is conserved in humans.
Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.
Self-assembly of replication protein A (RPA) into dynamic condensates after binding of single-stranded DNA promotes telomere maintenance in cancer cells.
