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个人简介
I am currently an Associate Professor under the Molecular Imaging Program at Stanford (MIPS), in the Department of Radiology at Stanford University. I have more than 16 years of experience in the use of different in vivo imaging modalities (Bioluminescence, Fluorescence, PET, SPECT and CT) for monitoring different cellular events in mice and rats. My research group mainly focuses on developing new imaging assays for studying different cellular signal transduction networks in living animals. Specifically, we are interested in
developing imaging assays to study post translational modifications of proteins, such as protein-methylation, protein-phosphorylation, and protein-sumoylation, in living animals. We have applied our extensive experience in molecular biology to develop several in vivo imaging assays, which can be used for monitoring basic cellular
processes, such as drug modulated protein-protein interactions, protein-phosphorylation, protein-methylation, protein sumoylation, and protein folding, in living animals. We have developed split-reporter protein complementation systems for various reporter genes (luciferases, fluorescent proteins, and thymidine kinase), and currently use them to design various imaging sensors to study various cellular processes. Mainly we are using these assays for studying protein cross talks involved in estrogen receptor signaling, Nrf2- mediated drug resistance in cancer therapy, p53-sumoylation in cancer, imaging tumor microenvironment in cancers, imaging
cytokine signaling in cancer, and APP and Tau protein sumoylations in Alzheimer’s disease. My research group is also working on imaging gene- and microRNA-based therapeutics in cancers (breast cancer, hepatocellular carcinoma, and glioma). We are currently exploring the role of the Nrf2-pathway for acquired chemoresistance in cancer therapy, as well as the activation of cellular Nrf2 to improve antioxidant potentials of
cancer therapy and stress-mediated β-cell apoptosis in diabetes. In addition, my lab collaborates with Dr. Willmann’s lab in developing ultrasound-microbubble (US-MB) triggered drug delivery strategies for improved cancer therapy, and Dr. Massoud’s lab in developing super selective microRNA delivery to brain to improve glioma therapy.
developing imaging assays to study post translational modifications of proteins, such as protein-methylation, protein-phosphorylation, and protein-sumoylation, in living animals. We have applied our extensive experience in molecular biology to develop several in vivo imaging assays, which can be used for monitoring basic cellular
processes, such as drug modulated protein-protein interactions, protein-phosphorylation, protein-methylation, protein sumoylation, and protein folding, in living animals. We have developed split-reporter protein complementation systems for various reporter genes (luciferases, fluorescent proteins, and thymidine kinase), and currently use them to design various imaging sensors to study various cellular processes. Mainly we are using these assays for studying protein cross talks involved in estrogen receptor signaling, Nrf2- mediated drug resistance in cancer therapy, p53-sumoylation in cancer, imaging tumor microenvironment in cancers, imaging
cytokine signaling in cancer, and APP and Tau protein sumoylations in Alzheimer’s disease. My research group is also working on imaging gene- and microRNA-based therapeutics in cancers (breast cancer, hepatocellular carcinoma, and glioma). We are currently exploring the role of the Nrf2-pathway for acquired chemoresistance in cancer therapy, as well as the activation of cellular Nrf2 to improve antioxidant potentials of
cancer therapy and stress-mediated β-cell apoptosis in diabetes. In addition, my lab collaborates with Dr. Willmann’s lab in developing ultrasound-microbubble (US-MB) triggered drug delivery strategies for improved cancer therapy, and Dr. Massoud’s lab in developing super selective microRNA delivery to brain to improve glioma therapy.
研究兴趣
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Cancer Researchno. 6_Supplement (2024): 68-68
Yanrong Zhang, Jing Wang,Sara Natasha Ghobadi,Haiyan Zhou,Ai Huang,Marco Gerosa,Qingyi Hou,Olivier Keunen,Anna Golebiewska, Frezghi G Habte,Gerald A Grant,Ramasamy Paulmurugan,
Ultrasound in medicine & biologyno. 3 (2023): 455-455
Journal of the Acoustical Society of Americano. 3_supplement (2023): A138-A138
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Magnetic resonance imaging (2023): 92-101
bioRxiv : the preprint server for biologyno. 18 (2023): 5433-5445
crossref(2023)
RSC CHEMICAL BIOLOGYno. 12 (2023): 1043-1049
Iyan Warren,Michael M Moeller,Daniel Guiggey, Alexander Chiang,Mitchell Maloy,Ogechi Ogoke,Theodore Groth,Tala Mon,Saber Meamardoost,Xiaojun Liu,Sarah Thompson, Antoni Szeglowski,
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