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Michael Tyers studies the structure and control of biological interaction networks at the protein, genetic and chemical level. His group has implemented systematic proteomic, genetic, phenotypic and chemical-genetic screens to interrogate and manipulate network function, with a focus on the control of cell growth and division by the ubiquitin-proteasome system, in both yeast and human cell systems. His group also uses biophysical, biochemical, structural and mathematical modelling methods to understand the dynamics of protein recognition within these networks. Most recently, his group has developed a synthetic biology platform to discover natural-product like molecules as novel chemical probes and early stage drug leads.
Michael Tyers studies the structure and control of biological interaction networks at the protein, genetic and chemical level. His group has implemented systematic proteomic, genetic, phenotypic and chemical-genetic screens to interrogate and manipulate network function, with a focus on the control of cell growth and division by the ubiquitin-proteasome system, in both yeast and human cell systems. His group also uses biophysical, biochemical, structural and mathematical modelling methods to understand the dynamics of protein recognition within these networks. Most recently, his group has developed a synthetic biology platform to discover natural-product like molecules as novel chemical probes and early stage drug leads.
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论文共 175 篇作者统计合作学者相似作者
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Maksym Korablyov,Cheng-Hao Liu,Moksh Jain, Almer M. van der Sloot, Eric Jolicoeur, Edward Ruediger,Andrei Cristian Nica,Emmanuel Bengio, Kostiantyn Lapchevskyi,Daniel St-Cyr,Doris Alexandra Schuetz,Victor Ion Butoi,
arxiv(2024)
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Journal of Biological Chemistryno. 3 (2023): 103343-103343
arxiv(2023)
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MOLECULAR CELLno. 22 (2023): 4078-4092.e6
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S154-S154
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