基本信息
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Career Trajectory
Bio
Chun-Nam Lok
Research Assistant Professor, Honorary Assistant Professor,
Department of Chemistry, The University of Hong Kong.
Education:
B. Sc. (HKBU); Ph.D. (HK)
Research Experience:
Postdoctoral Fellow,
HKU, McGill University and Queen’s University, Canada.
Research Interests:
Metals in Biology and Medicine, Chemical Biology and Proteomics, Drug Discovery
Selected Publications:
1. Zou T, Lok CN, Wan PK, Zhang ZF, Fung SK, Che CM (2017). Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium. Curr. Opin. Chem. Biol.. 43:30-36.
2. Fung SK, Zou T, Cao B, Lee PY, Fung EYM., Hu D, Lok CN and Che CM (2017). Cyclometallated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets. Angew. Chem. Int. Ed., 2017, 56: 3892-3896
3. Hamdi A, Garcia-Santos D, Lok CN, Schranzhofer M and Ponka P (2017) Role of Heme in the Regulation of Transferrin Receptor Expression in Erythroid Cells. Blood Supplement 130:3495;
4. Fong TT, Lok CN, Chung CY, Fung YM, Chow PK, Wan PK, Che CM (2016) Cyclometalated Palladium(II) N-Heterocyclic Carbene Complexes: Anticancer Agents for Potent In Vitro Cytotoxicity and In Vivo Tumor Growth Suppression. Angew Chem Int Ed. 55: 11935-9.
5. Hu, D., Liu, Y., Lai, Y.S., Tong, K.C., Fung, Y.M., Lok, C.N., Che, C.M. (2016) Anticancer Gold(III) prophyrins target mitochondrial chaperon Hsp60. Angew. Chem. Int. Ed. 55: 1387-91
6. Sy, L.K., Lok, C.N., Wang, J.Y., Liu Y., Cheng, L., Wan, P.K., Leung, C.T., Cao, B., Kwong, W.L., Chang, R.C.C., Che, C.M. (2016) Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ lowering modulators of amyloid precursor protein processing. Chem. Sci. 7: 3206-14
7. Fung SK, Zou T, Cao B, Chen T, To WP,Yang C, Lok CN, Che CM (2016), Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA. Nat. Commun. 7:10655.
8. Zou, T., Lum, C.T., Lok, C.N., Zhang, J.J., Che, C.M. (2015). Chemical biology of anticancer gold(III) and gold(I) complexes. Chem. Soc. Rev. 2015, 44: 8786-801
9. Lin, I.W., Lok, C.N. , Che, C.M. (2014) Biosynthesis of silver nanoparticles from silver(I) reduction by the periplasmic nitrate reductase c-type cytochrome subunit NapC in a silver resistant E .coli. Chem. Sci. , 5: 3144-50
10. Lok C.N., Zou T.T., Zhang J.J., Lin I.W., Che C.M. (2014) Controlled release systems for metal based nanomedicine: encapsulated/self-assembled nanoparticles of anticancer gold(III)/platinum(II) complexes and antimicrobial silver nanoparticles. Adv. Mater. 26: 5550-7
11. Lin I.W., Lok C.N., Yan K., Che C.M. (2013) A silver complex of N,N'-disubstituted cyclic thiourea as an anti-inflammatory inhibitor of IκB kinase. Chem Commun (Camb) 49: 3297-9.
12. Lok C.N., Sy L.K., Liu F., Che C.M. (2011) Activation of autophagy of aggregation-prone ubiquitinated proteins by timosaponin A-III. J Biol Chem. 286:31684-96.
13. Yan K., Lok C.N., Bierla K., Che C.M. (2010) Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase. Chem Commun (Camb). 46:7691-3.
15. Sy L.K., Yan S.C., Lok C.N., Man R.Y., Che C.M. (2008) Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells. Cancer Res. 68:10229-37.
16. Lok, C.N., Ho. C.M., Chen, R., Tam. P.K., Chiu, J.F. and Che, C.M (2008) Proteomic identification of Cus system as a major determinant of constitutive Escherichia coli silver resistance of chromosomal origin. J. Proteome Res. 7: 2351-2356
17. Lok, C.N., Ho. C.M., Chen, R., He, Q.Y., Yu. W.Y, Sun, H.Z., Tam. P.K., Chiu, J.F. and Che, C.M (2007). Silver nanoparticles: partial oxidation and antibacterial activities. J. Biol. Inorg. Chem. 12 : 527-34.
18. Lok, C.N., Ho, C.M., Chen, R., He, Q.Y., Yu, W.Y., Sun H.Z., Tam P.K., Chiu, J.F., and Che, C.M. (2006) Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J. Proteome Res. 5: 916-
19. Lok, C.N., Lang, A.J., Mirski, S.E.L. and Cole, S.P.C. (2002) Characterization of the human topoisomerase II beta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1(Sp1)-binding sites. Biochem. J. 368: 741-51
20. Lok, C.N., Viazovkina K., Min, K.L., Nagy, E., Wilds, C.J., Damha M.J., and Parniak M.A. (2002) Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2’-deoxy-2’-fluoro-D-arabinose and 2’-deoxyribose nucleotides. Biochemistry 41: 3457-67
21. Lok, C.N. and Ponka, P. (2000) Identification of an erythroid active element in the transferrin receptor gene. J. Biol. Chem. 275 :24185-90
22. Lok, C.N. and Ponka, P. (1999) Identification of a hypoxia response element in the transferrin receptor gene. J. Biol. Chem. 274: 24147-52
Research Interests
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Israel journal of chemistry/Israel Journal of Chemistry (2016): 833
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