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Stress and fear play important roles in our lives, from influencing daily behaviors to precipitating symptoms of mental health disorders. My laboratory is performing multi-level analyses toward understanding the neurobiology of stress and fear. Specifically, we investigate how stress alters hippocampal plasticity and multiple brain-memory systems, and how fear memories are formed. These investigations consist of employing lesion, intra-cerebral drug infusion, and in vitro and in vivo neurophysiological recording techniques. Recently, we began employing 'predator-like' robots and 'closed economy' (self-contained living setting comprised of safe nest and dangerous foraging zones) to investigate defensive behaviors of rats in semi-naturalistic, dynamic risky environments. These ecologically-relevant studies address the neuronal basis of the basic approach-avoid conflicts that contribute to human psychopathologies.
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Ivana L. Bussi,Miriam Ben-Hamo, Luis E. Salazar Leon, Leandro P. Casiraghi, Victor Y. Zhang, Alexandra F. Neitz, Jeffrey Lee,Joseph S. Takahashi,Jeansok J. Kim,Horacio O. de la Iglesia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 13 (2024): e2316841121-e2316841121
Neuroscience letters (2020): 135245-135245
Social Science Research Network (2018)
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