基本信息
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Career Trajectory
Bio
My research focus is on environmental, chemically induced neurodegenerative processes capable of producing CNS disorders such as Parkinson’s and Alzhimer’s Disease. I have made several fundamental advances in signal transduction mechanisms associated with cell death processes by exposure to the chemicals such as cyanide and manganese. Mitochondrial dysfunction is an early event in the neurodegenerative processes induced by these select agents. Reduced ATP levels, increased reactive oxygen species (ROS), impaired calcium homeostasis, and altered mitochondrial permeability are characteristic mitochondrial defects (Prabhakaran et al., 2005). In many neurodegenerative disorders, specific subsets of neurons degenerate while others are unaffected. Despite the clear association of mitochondrial dysfunction with neurodegenerative disease the molecular mechanisms of selective vulnerability are poorly understood. The primary focus of my research is on selective vulnerability of the nervous system to neurotoxic agents such as Cyanide, Manganese and Particulate Matter including Nano Materials. and identification of novel therapeutic agents to treat neurodegenerative conditions.
Research Interests
Papers共 45 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
合作者
合作机构
Nithin Krisshna Gunasekaran, Prathima Prabhu Tumkur, Nicole Nazario Bayon,Krishnan Prabhakaran, Wondwossen D. Arasho,Joseph Hall,Govindarajan T. Ramesh
Energy and environment focusno. 1 (2023): 83-89
Materials expressno. 9 (2022): 1211-1215
Nanomanufacturingno. 3 (2021): 176-189
Journal of Nanosciences Research & Reportspp.1-5, (2020)
Frontiers in Neuroscience (2019)
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Author Statistics
#Papers: 44
#Citation: 1283
H-Index: 21
G-Index: 35
Sociability: 4
Diversity: 3
Activity: 0
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