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All animals have evolved strategies to deal with damage due to injury or disease, but the ability to regenerate lost or damaged organs and appendages varies greatly in different species. Unfortunately, humans and other mammals are quite poor at regenerating, while other vertebrates, like salamanders and fish, can efficiently re-grow lost limbs/fins and regenerate many internal organs including their hearts. Currently it is a mystery why mammals can’t do what these lower vertebrates achieve. We hope that elucidating the mechanisms that zebrafish use to regulate regeneration will one day result in therapies aimed at activating regenerative potential in human organs.
Unlike mammals, zebrafish can completely and repeatedly regenerate lost appendages, that is their fins. This occurs via formation of a population of progenitor cells, the blastema, which contains the precursors of the regenerating tissue. How the blastema forms is a central question in regeneration research. Intriguingly, we have found that mature osteoblasts dedifferentiate and give rise to blastema cells after fin injury. The fact that differentiated cells, and not stem cells, represent important source cells for tissue regeneration has recently been recognized also in several other systems. Currently, we aim to elucidate the molecular mechanisms regulating this fascinating process of cellular plasticity.
In addition, we are interested in understanding the molecular pathways regulating regenerative growth and patterning. We have found that Wnt/beta-catenin signaling is required for formation and proliferation of the blastema; intriguingly however, it acts largely indirectly and orchestrates regenerative growth via secondary signals. Currently, we aim to elucidate how Wnt signaling sets up organizing centers within the blastema.
Unlike mammals, zebrafish can completely and repeatedly regenerate lost appendages, that is their fins. This occurs via formation of a population of progenitor cells, the blastema, which contains the precursors of the regenerating tissue. How the blastema forms is a central question in regeneration research. Intriguingly, we have found that mature osteoblasts dedifferentiate and give rise to blastema cells after fin injury. The fact that differentiated cells, and not stem cells, represent important source cells for tissue regeneration has recently been recognized also in several other systems. Currently, we aim to elucidate the molecular mechanisms regulating this fascinating process of cellular plasticity.
In addition, we are interested in understanding the molecular pathways regulating regenerative growth and patterning. We have found that Wnt/beta-catenin signaling is required for formation and proliferation of the blastema; intriguingly however, it acts largely indirectly and orchestrates regenerative growth via secondary signals. Currently, we aim to elucidate how Wnt signaling sets up organizing centers within the blastema.
研究兴趣
论文共 91 篇作者统计合作学者相似作者
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Chiara Bongiovanni,Hanna Bueno-Levy,Denise Posadas Pena, Irene Del Bono,Carmen Miano, Stefano Boriati,Silvia Da Pra,Francesca Sacchi, Simone Redaelli, Max Bergen,Donatella Romaniello,Francesca Pontis,Riccardo Tassinari, Laura Kellerer,Ilaria Petraroia,Martina Mazzeschi,Mattia Lauriola,Carlo Ventura,Stephan Heermann,Gilbert Weidinger, Eldad Tzahor, Gabriele D'Uva
Current Biologyno. 16 (2024): R774-R776
Mohan Dalvoy Vasudevarao,Denise Posadas Pena,Michaela Ihle,Chiara Bongiovanni,Pallab Maity, Simone Redaelli, Kathrin Happ, Dominik Geissler,Hossein Falah Mohammadi,Melanie Rall-Scharpf,Chi-Chung Wu,Arica Beisaw,Karin Scharffetter-Kochanek,Gabriele D’Uva, Lisa Wiesmüller,Gilbert Weidinger
crossref(2024)
Chiara Bongiovanni,Hanna Bueno-Levy,Denise Posadas Pena, Irene Del Bono, Simone Redaelli, Max Bergen,Silvia Da Pra,Francesca Sacchi,Carmen Miano, Stefano Boriati,Francesca Pontis,Donatella Romaniello,Martina Mazzeschi,Ilaria Petraroia,Riccardo Tassinari, Laura Kellerer, Mattia Lauriola,Carlo Ventura,Stephan Heermann,Gilbert Weidinger,Eldad Tzahor,Gabriele D’Uva
Cell Reports (2023)
Mirja Harms, Rikke Fabech Hansson,Andrea Gilg,Yasser Almeida-Hernandez,Jessica Loeffler,Armando Rodriguez-Alfonso,Monica M. W. Habib,Dan Albers,Nermin S. Ahmed,Ashraf H. Abadi,Gordon Winter,Volker Rasche,Ambros J. Beer,Gilbert Weidinger,Nico Preising,Ludger Staendker,Sebastian Wiese,Elsa Sanchez-Garcia,Alexander N. Zelikin,Jan Muench
Journal of medicinal chemistryno. 22 (2023): 15189-15204
Mirja Harms,Yasser Almeida-Hernández, Armando Rodríguez Alfonso,Monica Habib,Andrea Gilg,Dan Albers,Nermin Ahmed,Ashraf Abadi,Gilbert Weidinger, Ludger Ständker,Sebastian Wiese,Elsa Sanchez-Garcia,Jan Münch
Authorea (Authorea) (2022)
DEVELOPMENTAL BIOLOGY (2022): 226-237
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作者统计
#Papers: 94
#Citation: 6413
H-Index: 44
G-Index: 73
Sociability: 6
Diversity: 3
Activity: 55
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