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个人简介
Since my University studies (Biochemistry), I have been fascinated by the mechanisms that allow plants to grow under adverse and changing conditions. After obtaining my BSc in Biochemistry at the University of Seville (US) and completing a Master in Plant Molecular Biology, I obtained an FPU Fellowship to pursue my PhD. As FPU fellow at the Plant Biochemistry and Photosynthesis (CSIC-US), I worked on the identification and characterization of the elements involved in starch synthesis in plants. We demonstrated the critical role of the Starch Synthase (SS) Class IV (SS4) in the initiation of starch granules (Plant Cell, 2009; J Exp Bot, 2009; Plant Biotech J, 2011; Plant J, 2013), and showed that the exceedingly high accumulation of ADP-glucose in the ss3/ss4 double mutant inhibited the synthesis of chlorophyll and carotenoids and compromised photosynthesis (Plant Physiol, 2013). Last, we characterize the protein SS4 and the structural determinants of its subcellular localization (J Biol Chem, 2016). Part of our work was patented in 2010 (US2012/0102597A1) and my PhD thesis was awarded with the Extraordinary Doctoral Award from US. During this period, I stayed in different research institutes establishing fruitful collaborations. Moreover, I collaborated with the IBVF-US in teaching assignments and several outreach activities.
After my PhD, I did a first postdoc at the Institute of Natural Resources and Agrobiology from Seville (CSIC) where I pursued research regarding plant K nutrition and salt tolerance. We showed that AtHAK5 (that mediates K nutrition at low external concentrations) transport activity is post-transcriptionally upregulated by phosphorylation by CIPK23 (Plant Physiol, 2015, Frontiers, 2019). We also unravelled the structural domains of AtHAK5 and identified its phosphorylation site by CIPK23 (submitted to Plant Physiology). Furthermore, we published a complete structural description of CIPK23 that has established the basis for various activation states of CIPKs (PNAS, 2014). Regarding the salt tolerance of plants, we sought to understand how the increase of extracellular Na is translated into a signal relay which leads to the activation of the Salt Overly Sensitive (SOS) pathway to prevent the accumulation of Na to toxic levels. In particular, I was interested to determine whether changes in cytosolic pH could be involved in the signalling of salt stress. As part of this project, I successfully applied an EMBO Short-Term Fellowship to make a 3-month stay at Centre for Organismal Studies (COS, Heidelberg University, UHei), where I got exciting preliminary results to design and write my own project. During this period, I also got the ANECA Assistant Professor Accreditation and completed a Master in Teaching (MAES, US).
In 2018 I was awarded with a Marie Skłodowska-Curie Individual Fellowship (European programme Horizon 2020) to implement my project sigNal at COS (UHei). The overall aim of sigNal project was to gain novel insights into the early steps in the sensing and regulation of the salt stress response, for a better understanding of the salinity tolerance mechanisms of plants. This project has been particularly relevant from a methodological point of view, since R-GECO1-E2GFP has been used to monitor simultaneously changes in cytosolic Ca and pH. The manuscript is in progress.
In March 2021 I got a posion at VEROVACCiNES, a biopharmaceutical spin-off company of the Martin Luther University Halle-Wittenberg. Here, we develop innovative vaccine solutions, to protect animals against infectious diseases. Currently, I am project leader in the poultry IB vaccine project and responsible for the formulation development.
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