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I am interested in the biophysics and mechanisms of mechanobiology, i.e., the role of mechanical force in the evolution of structure and function in human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) including related topics of cell adhesion, downstream signaling and mechanoresponse. Our lab has developed technologies to enhance maturity in hiPSC-CMs and make quantitative measurements of cell responses to drugs or in the presence of disease mutations. Our research interests span from custom microtechnologies for small-scale mechanical measurements to questions of how mechanics mediate biological signaling. Normal force sensing, remodeling and load bearing by cells are essential for basic life processes. For example, we study signaling, and mechanisms and forces of cell adhesion in coordinating cell behavior and response to mechanical changes, as well as the development and response of stem cells and cardiac myocytes to mechanical loading. We design and fabricate most of our own tools and sensors and are interested in reliable and quantitative measurements of fundamental biophysics to answer novel questions in the areas of physiology, cardiology, stem cells, cell biology, and neuroscience.
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Kerry V. Lane,Liam P. Dow, Erica A. Castilloa,Rémi Boros, Sam D. Feinstein,Gaspard Pardon,Beth L. Pruitt
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Biophysical journalno. 3S1 (2023): 264a-264A
BIOPHYSICS REVIEWSno. 2 (2023): 021303-021303
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