基本信息
浏览量:82
职业迁徙
个人简介
Converting a fertilized egg into an adult human requires TRILLIONS of cell divisions. Our research into the mechanisms that restrict nuclear DNA replication during cell division to one complete copy of the genome each time a cell divides revealed mechanisms by which some cells, such as trophoblast stem cells and megakaryoblasts, are developmentally programmed to differentiate into nonproliferating polyploid cells via 'endoreplication', a process in which mitosis is bypassed and a second S-phase ensues. Our research into the distinctions between stem cells, differentiated cells and cancer cells that regulate genome duplication led to the identification of genes essential to prevent 'unscheduled endoreplication', an event that promotes cancer, as well as genes essential to prevent 'DNA re-replication', an aberrant form of replication in which some regions are duplicated more than once during a single S-phase. Induction of DNA re-replication can selectively kill cancer cells with little or no harm to normal cells. This discovery led to the identification of a family of small molecules that can selectively kill cancer cells by disrupting lysosome homeostasis, a stable equilibrium essential for degrading and recycling cellular components to provide energy and nutrients for growth and proliferation. Our current goal is to determine the therapeutic potential of these molecules, and the mechanistic basis that distinguishes sensitive from insensitive cells.
Research
Genome Duplication and Cancer
DNA Replication Origins
Regulation of ORC activity (The "ORC cycle")
Gene Expression at the Beginning of Mammalian Development
Early Research
Research
Genome Duplication and Cancer
DNA Replication Origins
Regulation of ORC activity (The "ORC cycle")
Gene Expression at the Beginning of Mammalian Development
Early Research
研究兴趣
论文共 227 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Molecular oncology (2024)
crossref(2023)
Yi Zhang,Zhuqing Li,Qiang Hao,Wei Tan, Jing Sun,Jing Li,Chi‐Wei Chen,Zongzhu Li,Yunxiao Meng,Yuan Zhou, Zhen Han,Huadong Pei,Melvin L. DePamphilis, Wei-Ping Zhu
openalex(2023)
Wei-Ping Zhu,Melvin L. DePamphilis
openalex(2023)
加载更多
作者统计
#Papers: 228
#Citation: 14790
H-Index: 70
G-Index: 117
Sociability: 6
Diversity: 3
Activity: 11
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn