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个人简介
His many fundamental discoveries have concerned the biochemical mechanisms and physiological regulation of protein breakdown in cells and the importance of this process in human disease. He first demonstrated that misfolded proteins are selectively degraded by an ATP-dependent process in bacterial and animal cells, and then demonstrated the existence of the non-lysosomal ATP-dependent pathway for protein breakdown, now termed the ubiquitin-proteasome pathway. His laboratory first described the roles of the 26S and 20S proteasomes in the degradation of ubiquitinated proteins and discovered the ATP-dependent proteases responsible for protein degradation in bacteria and mitochondria. In addition, their lab has played a major role in elucidating their novel biochemical mechanisms and modes of regulation. Also of very wide impact have been Dr. Goldberg’s studies showing that the ubiquitin-proteasome pathway is critical in the excessive protein breakdown causing muscle atrophy in many disease states, in antigen presentation to the immune system, as well as in the clearance of misfolded aggregation-prone proteins. He and his colleagues also first introduced proteasome inhibitors widely used as research tools (e.g. MG132), and he initiated the development of the proteasome inhibitor, Bortezomib/Velcade, which is now used worldwide as the standard treatment of the blood cancer, multiple myeloma. Dr. Goldberg’s various studies have not only advanced our understanding of many areas of biology and disease mechanisms, but have also had a major impact on biotechnology and medical practice.
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论文共 273 篇作者统计合作学者相似作者
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Zhong-Qiu Yu,Jenny Carmichael,Galen A Collins, Maria Daniela D'Agostino, Mathieu Lessard,Helen V Firth, Pooja Harijan,Andrew E Fry,John Dean,Jiuchun Zhang,Usha Kini,Alfred L Goldberg,
Human molecular genetics (2024)
bioRxiv : the preprint server for biology (2023)
Mengying Zhou,Rui Fang,Louis Colson,Katherine A Donovan,Moritz Hunkeler, Yuyu Song,Can Zhang,Siyi Chen,Dong-Hoon Lee,Gary A Bradshaw, Robyn Eisert,Yihong Ye,
bioRxiv : the preprint server for biology (2023)
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