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职业迁徙
个人简介
My early work was focusing on the biology and function of small nuclear RNAs and later I was heavily involved in lung cancer gene therapy and functional studies of oncogenes. For the past decade, I have been involved in studies investigating the role of biomarkers in improving cancer risk and outcome prediction. I also have a keen interest in genome-wide molecular profiling (SNP array CGH, mRNA, microRNA, and methylation array) of somatic tissues, including premalignant and malignant tissues, to identify biomarkers of diagnosis and prognosis of cancer. My current major research projects are the role of epigenetics (e.g., DNA methylation) in predicting aggressive prostate cancer and racial disparity of prostate cancer. I have an ongoing CPRIT grant to study DNA methylation in peripheral blood as biomarkers of aggressive prostate cancer. We are extending DNA methylation research to address racial disparity issue in African Americans who have a greater incidence of prostate cancer and higher mortality. DNA methylation sits at the interface between genetics and environment. Age, obesity, smoking and ethnicity, established risk and prognostic factors for PCa, have major impact on DNA methylation. DNA methylation in peripheral blood leukocytes (PBLs) may also infer the state of immune system. Our hypothesis is that PCa in AA men exhibit racial specific PBL epigenome associated with aggressive PCa. A secondary hypothesis is that AA patients have a distinct leukocyte composition that may indicate weaker cellular immunity and thus more aggressive disease. Another cancer site that my lab is working on is soft tissue sarcoma (STS): to identify genetic and phenotypic susceptibility factors for STS. In addition, we are also working on functional studies of genetic variations, DNA methylation and microRNAs in the context of cancer risk and outcomes.
My major research interests are to identify genetic susceptibility genes to cancer development, intermediate biomarkers of cancer risk and outcomes, and circulating biomarkers for cancer risk and early detection. My current major research focuses are to investigate the role of epigenetics (e.g., DNA methylation) in predicting aggressive prostate cancer and racial disparity of prostate cancer and to identify circulating methylated DAN as biomarkers for early detection and prognosis using whole genome methylation array and bisulfite next generation sequencing technology. I have an ongoing CPRIT grant to study DNA methylation in peripheral blood as biomarkers of aggressive prostate cancer. We are extending DNA methylation research to address racial disparity issue in African Americans who have a greater incidence of prostate cancer and higher mortality. DNA methylation sits at the interface between genetics and environment. Age, obesity, smoking and ethnicity, established risk and prognostic factors for PCa, have major impact on DNA methylation. DNA methylation in peripheral blood leukocytes (PBLs) may also infer the status of immune system. Our hypothesis is that PCa in AA men exhibit racial specific PBL epigenome associated with aggressive PCa. A secondary hypothesis is that AA patients have a distinct leukocyte composition that may indicate weaker cellular immunity and thus more aggressive disease. In addition, we are also working on functional studies of genetic variations, DNA methylation and microRNAs in the context of cancer risk and outcomes.
My major research interests are to identify genetic susceptibility genes to cancer development, intermediate biomarkers of cancer risk and outcomes, and circulating biomarkers for cancer risk and early detection. My current major research focuses are to investigate the role of epigenetics (e.g., DNA methylation) in predicting aggressive prostate cancer and racial disparity of prostate cancer and to identify circulating methylated DAN as biomarkers for early detection and prognosis using whole genome methylation array and bisulfite next generation sequencing technology. I have an ongoing CPRIT grant to study DNA methylation in peripheral blood as biomarkers of aggressive prostate cancer. We are extending DNA methylation research to address racial disparity issue in African Americans who have a greater incidence of prostate cancer and higher mortality. DNA methylation sits at the interface between genetics and environment. Age, obesity, smoking and ethnicity, established risk and prognostic factors for PCa, have major impact on DNA methylation. DNA methylation in peripheral blood leukocytes (PBLs) may also infer the status of immune system. Our hypothesis is that PCa in AA men exhibit racial specific PBL epigenome associated with aggressive PCa. A secondary hypothesis is that AA patients have a distinct leukocyte composition that may indicate weaker cellular immunity and thus more aggressive disease. In addition, we are also working on functional studies of genetic variations, DNA methylation and microRNAs in the context of cancer risk and outcomes.
研究兴趣
论文共 348 篇作者统计合作学者相似作者
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Cancer Genomics & Proteomicsno. 2 (2024): 144-157
Jie Ping,Guochong Jia,Qiuyin Cai,Xingyi Guo,Ran Tao,Christine Ambrosone,Dezheng Huo,Stefan Ambs,Mollie E. Barnard,Yu Chen,Montserrat Garcia-Closas,Jian Gu,Jennifer J. Hu,Esther M. John,Christopher I. Li,Katherine Nathanson,Barbara Nemesure,Olufunmilayo I. Olopade,Tuya Pal,Michael F. Press,Maureen Sanderson,Dale P. Sandler,Toshio Yoshimatsu,Prisca O. Adejumo,Thomas Ahearn,Abenaa M. Brewster,Anselm J. M. Hennis,Timothy Makumbi,Paul Ndom,Katie M. O'Brien,Andrew F. Olshan,Mojisola M. Oluwasanu,Sonya Reid,Song Yao,Ebonee N. Butler,Maosheng Huang,Atara Ntekim,Bingshan Li,Melissa A. Troester,Julie R. Palmer,Christopher A. Haiman,Jirong Long,Wei Zheng
NATURE COMMUNICATIONSno. 1 (2024)
Bo-Ren Wang, Hung-Huan Ma,Chao-Hsiang Chang,Cheng-Hsi Liao,Wen-Shin Chang,Mei-Chin Mong,Ya-Chen Yang,Jian Gu, Da-Tian Bau,Chia-Wen Tsai
Lifeno. 7 (2024): 801-801
Xiaohui Sun, Shiv P. Verma,Guochong Jia,Xinjun Wang,Jie Ping,Xingyi Guo,Xiao-Ou Shu,Jianhong Chen,Andriy Derkach,Qiuyin Cai,Xiaolin Liang,Jirong Long,Kenneth Offit,Jung H. Oh,Anne S. Reiner,Gordon P. Watt,Meghan Woods,Yaohua Yang,Christine B. Ambrosone,Stefan Ambs,Yu Chen,Patrick Concannon,Montserrat Garcia-Closas,Jian Gu,Christopher A. Haiman,Jennifer J. Hu,Dezheng Huo,Esther M. John,Julia A. Knight,Christopher I. Li,Charles F. Lynch,Lene Mellemkjaer,Katherine L. Nathanson,Barbara Nemesure,Olufunmilayo I. Olopade,Andrew F. Olshan,Tuya Pal,Julie R. Palmer,Michael F. Press,Maureen Sanderson,Dale P. Sandler,Melissa A. Troester,Wei Zheng,Jonine L. Bernstein,Matthew F. Buas,Xiang Shu
CANCER RESEARCHno. 15 (2024): 2533-2548
The Prostate/The prostateno. 7 (2024): 694-705
Mark P Purdue,Diptavo Dutta,Mitchell J Machiela,Bryan R Gorman,Timothy Winter, Dayne Okuhara, Sara Cleland,Aida Ferreiro-Iglesias,Paul Scheet,Aoxing Liu, Chao Wu,Samuel O Antwi,James Larkin,Stênio C Zequi,Maxine Sun,Keiko Hikino,Ali Hajiran,Keith A Lawson, Flavio Cárcano,Odile Blanchet,Brian Shuch,Kenneth G Nepple,Gaëlle Margue,Debasish Sundi,W Ryan Diver, A,Adrie van Bokhoven,Florencia Neffa,Kevin M Brown,Jonathan N Hofmann,Jongeun Rhee,Meredith Yeager,Nathan R Cole,Belynda D Hicks,Michelle R Manning,Amy A Hutchinson,Nathaniel Rothman,Wen-Yi Huang,W Marston Linehan,Adriana Lori,Matthieu Ferragu,Merzouka Zidane-Marinnes,Sérgio V Serrano,Wesley J Magnabosco,BioBank Japan Project, Ana Vilas,Ricardo Decia,Florencia Carusso,Laura S Graham, Kyra Anderson,Mehmet A Bilen,Cletus Arciero,Isabelle Pellegrin,Solène Ricard, FinnGen,Ghislaine Scelo,Rosamonde E Banks,Naveen S Vasudev,Naeem Soomro,Grant D Stewart,Adebanji Adeyoju, Stephen Bromage,David Hrouda, Norma Gibbons,Poulam Patel,Mark Sullivan,Andrew Protheroe, Francesca I Nugent,Michelle J Fournier, Xiaoyu Zhang,Lisa J Martin,Maria Komisarenko,Timothy Eisen,Sonia A Cunningham, Denise C Connolly,Robert G Uzzo,David Zaridze,Anush Mukeria,Ivana Holcatova,Anna Hornakova,Lenka Foretova,Vladimir Janout,Dana Mates,Viorel Jinga,Stefan Rascu,Mirjana Mijuskovic,Slavisa Savic,Sasa Milosavljevic,Valérie Gaborieau,Behnoush Abedi-Ardekani,James McKay,Mattias Johansson,Larry Phouthavongsy, Lindsay Hayman,Jason Li,Ilinca Lungu,Stephania M Bezerra,Aline G Souza, Claudia T G Sares,Rodolfo B Reis,Fabio P Gallucci,Mauricio D Cordeiro,Mark Pomerantz,Gwo-Shu M Lee,Matthew L Freedman,Anhyo Jeong,Samantha E Greenberg, Alejandro Sanchez,R Houston Thompson,Vidit Sharma,David D Thiel,Colleen T Ball,Diego Abreu,Elaine T Lam,William C Nahas, Viraj A Master,Alpa V Patel,Jean-Christophe Bernhard,Neal D Freedman,Pierre Bigot, Rui M Reis,Leandro M Colli,Antonio Finelli,Brandon J Manley,Chikashi Terao,Toni K Choueiri,Dirce M Carraro,Richard Houlston,Jeanette E Eckel-Passow,Philip H Abbosh,Andrea Ganna,Paul Brennan,Jian Gu,Stephen J Chanock
Guochong Jia,Jie Ping,Xingyi Guo,Yaohua Yang,Ran Tao,Bingshan Li,Stefan Ambs,Mollie E. Barnard,Yu Chen,Montserrat Garcia-Closas,Jian Gu,Jennifer J. Hu,Dezheng Huo,Esther M. John,Christopher I. Li,James L. Li,Katherine L. Nathanson,Barbara Nemesure,Olufunmilayo I. Olopade,Tuya Pal,Michael F. Press,Maureen Sanderson,Dale P. Sandler,Xiao-Ou Shu,Melissa A. Troester,Song Yao,Prisca O. Adejumo,Thomas Ahearn,Abenaa M. Brewster,Anselm J. M. Hennis,Timothy Makumbi,Paul Ndom,Katie M. O'Brien,Andrew F. Olshan,Mojisola M. Oluwasanu,Sonya Reid,Ebonee N. Butler,Maosheng Huang,Atara Ntekim,Huijun Qian,Haoyu Zhang,Christine B. Ambrosone,Qiuyin Cai,Jirong Long,Julie R. Palmer,Christopher A. Haiman,Wei Zheng
NATURE GENETICSno. 5 (2024): 819-826
Manal M. Hassan,Donghui Li,Younghun Han,Jinyoung Byun,Rikita I. Hatia,Erping Long,Jiyeon Choi,Robin Kate Kelley,Sean P. Cleary,Anna S. Lok,Paige Bracci,Jennifer B. Permuth,Roxana Bucur,Jian-Min Yuan,Amit G. Singal,Prasun K. Jalal,R. Mark Ghobrial,Regina M. Santella,Yuko Kono,Dimpy P. Shah,Mindie H. Nguyen,Geoffrey Liu,Neehar D. Parikh,Richard Kim,Hui-Chen Wu,Hashem El-Serag,Ping Chang, Yanan Li,Yun Shin Chun,Sunyoung S. Lee,Jian Gu,Ernest Hawk,Ryan Sun,Chad Huff,Asif Rashid,Hesham M. Amin,Laura Beretta,Robert A. Wolff,Samuel O. Antwi,Yehuda Patt,Lu-Yu Hwang,Alison P. Klein,Karen Zhang,Mikayla A. Schmidt,Donna L. White,John A. Goss,Saira A. Khaderi,Jorge A. Marrero,Francisco G. Cigarroa,Pankil K. Shah,Ahmed O. Kaseb,Lewis R. Roberts,Christopher I. Amos
Hepatology (2024)
Prostate cancer and prostatic diseasesno. 2 (2024): 339-347
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作者统计
#Papers: 348
#Citation: 15012
H-Index: 73
G-Index: 115
Sociability: 8
Diversity: 0
Activity: 3
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