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SYMPTOMATIC CAROTID ARTERY STENOSISCarotid artery stenosis is an important cause of stroke. Professor Martin Brown is the Chief Investigator responsible for organising, collecting data and analysing results from the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS) and the International Carotid Stenting Study (ICSS). These are multicentre randomised controlled trials comparing carotid endarterectomy with endovascular treatment (angioplasty with or without stenting) for recently symptomatic carotid stenosis. Early results from CAVATAS showed that endovascular treatment had similar major risks and effectiveness at prevention of stroke during 3 years compared with surgery with the advantage of avoiding minor complications such as cranial neuropathy. This research programme on carotid artery surgery and stenting has had substantial influence on practice and service delivery and the prevention of stroke from carotid artery atherosclerosis The preliminary results of CAVATAS have informed the National Clinical Guidelines for Stroke and the NICE recommendations on Carotid Stenting. ICSS is a follow on study from CAVATAS, designed to compare primary stenting (a newer technique) with carotid surgery. ICSS has promoted the prudent development of optimal carotid stenting in the UK and incorporates arrangements for training radiologists in carotid stenting. ICSS will complete recruitment of over 1,700 patients from more than 50 neuroscience centres in Europe, Canada, Australia and New Zealand in 2008. Locally, we are also undertaking a study to identify patients at increased risk of complications from carotid stenting. This uses a special magnetic coil to image the deposits of atherosclerosis causing the carotid narrowing, and ultrasound equipment to measure blood flow and detect small blood clots and other particles which break off from the patch of atherosclerosis.FACILITATION OF MULTICENTRE CLINICAL TRIALS
SYMPTOMATIC CAROTID ARTERY STENOSISCarotid artery stenosis is an important cause of stroke. Professor Martin Brown is the Chief Investigator responsible for organising, collecting data and analysing results from the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS) and the International Carotid Stenting Study (ICSS). These are multicentre randomised controlled trials comparing carotid endarterectomy with endovascular treatment (angioplasty with or without stenting) for recently symptomatic carotid stenosis. Early results from CAVATAS showed that endovascular treatment had similar major risks and effectiveness at prevention of stroke during 3 years compared with surgery with the advantage of avoiding minor complications such as cranial neuropathy. This research programme on carotid artery surgery and stenting has had substantial influence on practice and service delivery and the prevention of stroke from carotid artery atherosclerosis The preliminary results of CAVATAS have informed the National Clinical Guidelines for Stroke and the NICE recommendations on Carotid Stenting. ICSS is a follow on study from CAVATAS, designed to compare primary stenting (a newer technique) with carotid surgery. ICSS has promoted the prudent development of optimal carotid stenting in the UK and incorporates arrangements for training radiologists in carotid stenting. ICSS will complete recruitment of over 1,700 patients from more than 50 neuroscience centres in Europe, Canada, Australia and New Zealand in 2008. Locally, we are also undertaking a study to identify patients at increased risk of complications from carotid stenting. This uses a special magnetic coil to image the deposits of atherosclerosis causing the carotid narrowing, and ultrasound equipment to measure blood flow and detect small blood clots and other particles which break off from the patch of atherosclerosis.FACILITATION OF MULTICENTRE CLINICAL TRIALS
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Expert review of cardiovascular therapypp.1-7, (2024)
David Werring,Matthew Adams,Laura Benjamin,Martin Brown, Arvind Chandratheva,Peter Cowley,Joan Grieve, Fiona Humphries,Hans Rolf Jäger,Nicholas Losseff,Richard Perry,Robert Simister,
Neurologypp.107-198, (2024)
Journal of the neurological sciences (2023): 120743
Journal of vascular surgeryno. 3 (2023): 695-703
EUROPEAN JOURNAL OF RADIOLOGY (2023)
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Annals of neurologyno. 1 (2023): 43-54
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