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For over twenty-five years, I have been trying to understand how enzymes achieve their extraordinary catalytic power. To understand required determining their appearance. I began by developing crystallographic methods for direct observation of productive enzyme-substrate and enzyme-intermediate complexes which led to techniques for studying protein crystal structures at very low temperatures. We used these methods to obtain high-resolution information about several enzyme intermediates. We discovered that protein flexibility could be studied crystallographically, and we mapped the spatial distribution of protein motions as a function of temperature. In collaboration with Professor Dagmar Ringe of Brandeis University, we extended this work, helping develop methods for time-resolved protein crystallography, and applied them to obtain time-lapse pictures, at atomic resolution, of several enzymes in action. Recently, I have become interested in trying to combine the reductionist approach of biological chemistry with the whole-organism approach of genetics. Therefore, I took sabbatical in Professor Ira Herskowitz's lab at UC San Francisco to learn yeast genetics. In rediscovering the joy of working at the bench with my own hands, I have also found that "the awesome power of yeast genetics" lives up to its billing. In the future, I hope to use genetic as well as biochemical and biophysical tools to study the structure/function relationship as it applies to in vivo as well as in vitro function.
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论文共 25 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 48 (2020): 30710-30721
Man Ying Wong,Michael Lewis,James J Doherty,Yang Shi,Anil G Cashikar, Anna Amelianchik, Svitlana Tymchuk,Patrick M Sullivan,Mingxing Qian,Douglas F Covey,Gregory A Petsko,David M Holtzman,
Journal of neuroinflammationno. 1 (2020): 192-192
Stem cell reportsno. 3 (2018): 1046-1058
Sami J. Barmada,Shulin Ju,Arpana Arjun, Anthony Batarse,Hilary C. Archbold,Daniel Peisach,Xingli Li, Yuxi Zhang,Elizabeth M. H. Tank,Haiyan Qiu,Eric J. Huang,Dagmar Ringe,
Structure (London, England : 1993)no. 6 (2014): 899-910
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