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Research Synopsis
NMR spectroscopy is a unique method of studying proteins at the atomic level in solution, allowing us to determine their structure, function, and how they fold and unfold from their normal biological state. Understanding this is of major biomedical importance as a number of neurodegenerative diseases, such as Alzheimer’s, Parkinson's and the prion diseases, CJD and BSE, involve protein misfolding and partially and misfolded protein states. We have shown how NMR can be used to determine structural and dynamic information of such states, which provide a basis for identifying where and how to interrupt amyloidogenesis before the onset of neurodegeneration.
Recent highlights include the structure determination and biophysical characterisation of the disease-resistant form of prion protein, V127, in its normal cellular fold. Key regions of the protein which are associated with the development of prion diseases were identified, providing insights into its protective mechanism, and how prion protein misfolding is involved.
NMR spectroscopy is a unique method of studying proteins at the atomic level in solution, allowing us to determine their structure, function, and how they fold and unfold from their normal biological state. Understanding this is of major biomedical importance as a number of neurodegenerative diseases, such as Alzheimer’s, Parkinson's and the prion diseases, CJD and BSE, involve protein misfolding and partially and misfolded protein states. We have shown how NMR can be used to determine structural and dynamic information of such states, which provide a basis for identifying where and how to interrupt amyloidogenesis before the onset of neurodegeneration.
Recent highlights include the structure determination and biophysical characterisation of the disease-resistant form of prion protein, V127, in its normal cellular fold. Key regions of the protein which are associated with the development of prion diseases were identified, providing insights into its protective mechanism, and how prion protein misfolding is involved.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
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Journal of Molecular Biology/Journal of molecular biologyno. 15 (2023): 168158-168158
Savroop K. Bhamra,Parineeta Arora,Laszlo L. P. Hosszu,Jan Bieschke,Anthony R. Clarke,John Collinge,Parmjit S. Jat
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Thomas Coysh,Jaunmuktane Zane, Munier Nour, Miguel Barría,Holm-Mercer Leah,Hosszu Laszlo,Brandner Sebastian, Colin A. Smith, Connolly John,Simon Mead
openalex
Virusesno. 9 (2021)
Magnetic resonanceno. 2 (2021): 629-642
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作者统计
#Papers: 31
#Citation: 1101
H-Index: 17
G-Index: 22
Sociability: 5
Diversity: 2
Activity: 6
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