Jakob J Metzger - Max Delbrueck Center for Molecular Medicine (MDC)

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论文共 35 篇作者统计合作学者相似作者

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Mutant Huntingtin Impairs Neurodevelopment in Human Brain Organoids Through CHCHD2-mediated Neurometabolic Failure

Pawel Lisowski,Selene Lickfett,Agnieszka Rybak-Wolf,Carmen Menacho, Stephanie Le,Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra,Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth,Ruchika Anand, Linda A M Kulka,David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C Miller, Annett Böddrich, Amin Polzin,Ertan Mayatepek,Sebastian Diecke,Heidi Olzscha,Janine Kirstein,Cristina Ugalde,Spyros Petrakis, Sidney Cambridge,Nikolaus Rajewsky,Ralf Kühn,Erich E Wanker,Josef Priller,Jakob J Metzger,Alessandro Prigione

Nature communicationsno. 1 (2024): 7027-7027

引用0浏览0WOSNATURE引用

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

Pawel Lisowski,Selene Lickfett,Agnieszka Rybak-Wolf,Stephanie Le, Werner Dykstra,Barbara Mlody,Carmen Menacho, Philipp Roth, Yasmin Richter, Linda A. M. Kulka,Petar Glazar, Haijia Wu,David Meierhofer,Ivano Legnini, Max Otto,Duncan Miller,Nancy Neuendorf,Tobias Hahn,Narasimha Swamy Telugu,Annett Böddrich,Ertan Mayatepek,Sebastian Diecke,Heidi Olzscha,Janine Kirstein,Ralf Kühn,Sidney Cambridge,Nikolaus Rajewsky,Erich E. Wanker,Josef Priller,Jakob J. Metzger,Alessandro Prigione

bioRxiv (Cold Spring Harbor Laboratory) (2023)

引用0浏览0引用

Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington's disease models

Jakob J. Metzger, Carlota Pereda,Arjun Adhikari,Tomomi Haremaki,Szilvia Galgoczi,Eric D. Siggia,Ali H. Brivanlou,Fred Etoc

Cell Reports Methodsno. 9 (2022): 100297

引用4浏览0WOS引用

Depletion of Aneuploid Cells in Human Embryos and Gastruloids

Min Yang,Tiago Rito,Jakob Metzger,Jeffrey Naftaly,Rohan Soman,Jianjun Hu,David F. Albertini,David H. Barad,Ali H. Brivanlou,Norbert Gleicher

Nature Cell Biology（2021）

引用72浏览0WOSNATURE引用

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects

Szilvia Galgoczi,Albert Ruzo,Christian Markopoulos,Anna Yoney,Tien Phan-Everson,Shu Li,Tomomi Haremaki,Jakob J. Metzger,Fred Etoc,Ali H. Brivanlou

DEVELOPMENT（2021）

引用7浏览0WOS引用

A 3D Model of a Human Epiblast Reveals BMP4-driven Symmetry Breaking

Mijo Simunovic,Jakob J. Metzger,Fred Etoc,Anna Yoney,Albert Ruzo,Iain Martyn,Gist Croft, Dong Shin You,Ali H. Brivanlou,Eric D. Siggia

Nature cell biology（2019）

引用118浏览0WOSNATURE引用

118

Self-organizing Neuruloids Model Developmental Aspects of Huntington’s Disease in the Ectodermal Compartment

Tomomi Haremaki,Jakob J. Metzger,Tiago Rito,M. Zeeshan Ozair,Fred Etoc,Ali H. Brivanlou

Nature biotechnology（2019）

引用108浏览0WOSNATURE引用

108

WNT Signaling Memory is Required for ACTIVIN to Function As a Morphogen in Human Gastruloids

Anna Yoney,Fred Etoc,Albert Ruzo, Thomas Carroll,Jakob J. Metzger, Lain Martyn,Shu Li,Christoph Kirst,Eric D. Siggia,Ali H. Brivanlou

bioRxiv（2018）

引用69浏览0WOS引用

Synthetic Embryology: Controlling Geometry to Model Early Mammalian Development

Jakob J. Metzger,Mijo Simunovic,Ali H. Brivanlou

CURRENT OPINION IN GENETICS & DEVELOPMENT（2018）

引用17浏览0WOS引用

Molecular mechanism of symmetry breaking in a 3D model of a human epiblast

Mijo Simunovic,Jakob J Metzger,Fred Etoc,Anna Yoney,Albert Ruzo,Iain Martyn,Gist F. Croft,Ali H. Brivanlou,Eric D. Siggia

bioRxiv（2018）

引用5浏览0引用

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