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Molecular interactions drive all processes in life. Because of this enormous importance it is one pertinent demand in life sciences, systems biology and synthetic biology to characterize how these interactions drive biological processes and thus to decipher fundamentals of the biological language. The research group of Daniel Müller develops bionanotechnological methods that allow quantifying inter- and intramolecular interactions of biological processes. Currently these methods allow to image cells at nanometer resolution, to quantify and localize cellular interactions at molecular resolution and to observe how individual receptors of living cells communicate. Furthermore, recent developments of multiparametric nanoscopic tools allow to image cells, cellular membranes or membrane proteins and to simultaneously quantify and map multiple of their physical, chemical and biological properties. The continuous development of single-molecule force spectroscopy assays opens the possibility to quantify and structurally localize interactions that fold, stabilize and control the functional state of membrane proteins at physiological relevant conditions in lipid or cellular membranes.
Further we develop and apply nanotechnological tools to quantify the mechanical properties of animal cells in fundamental processes including adhesion, sorting, growth and mitosis. Whereas some of these tools allow to measure the adhesion of cells from the cellular to the molecular scale, others enable to characterize processes and mechanisms determining cell shape. Recently, these methods could be for example applied to discover new genes/proteins in regulating shape changes of mitotic cells or to mechanically control mitosis. Other examples include quantifying how membrane receptors regulate cell adhesion moelcules and which genes/proteins are key to this regulation. Very recently we developed, together with the group of Botond Roska, very efficient tools to genetically reprogram single neuronal cells in vitro and in vivo.
Molecular interactions drive all processes in life. Because of this enormous importance it is one pertinent demand in life sciences, systems biology and synthetic biology to characterize how these interactions drive biological processes and thus to decipher fundamentals of the biological language. The research group of Daniel Müller develops bionanotechnological methods that allow quantifying inter- and intramolecular interactions of biological processes. Currently these methods allow to image cells at nanometer resolution, to quantify and localize cellular interactions at molecular resolution and to observe how individual receptors of living cells communicate. Furthermore, recent developments of multiparametric nanoscopic tools allow to image cells, cellular membranes or membrane proteins and to simultaneously quantify and map multiple of their physical, chemical and biological properties. The continuous development of single-molecule force spectroscopy assays opens the possibility to quantify and structurally localize interactions that fold, stabilize and control the functional state of membrane proteins at physiological relevant conditions in lipid or cellular membranes.
Further we develop and apply nanotechnological tools to quantify the mechanical properties of animal cells in fundamental processes including adhesion, sorting, growth and mitosis. Whereas some of these tools allow to measure the adhesion of cells from the cellular to the molecular scale, others enable to characterize processes and mechanisms determining cell shape. Recently, these methods could be for example applied to discover new genes/proteins in regulating shape changes of mitotic cells or to mechanically control mitosis. Other examples include quantifying how membrane receptors regulate cell adhesion moelcules and which genes/proteins are key to this regulation. Very recently we developed, together with the group of Botond Roska, very efficient tools to genetically reprogram single neuronal cells in vitro and in vivo.
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Krishna Chaitanya Kasuba,Alessio Paolo Buccino,Julian Bartram,Benjamin M. Gaub, Felix J. Fauser,Silvia Ronchi,Sreedhar Saseendran Kumar,Sydney Geissler, Michele M. Nava,Andreas Hierlemann,Daniel J. Müller
Nature Nanotechnologypp.1-9, (2024)
Sophie Herzog,Gotthold Fläschner,Ilaria Incaviglia, Javier Casares Arias,Aaron Ponti,Nico Strohmeyer, Michele M. Nava,Daniel J. Müller
Nature Communicationsno. 1 (2024): 1-13
Hella Baumann,Melanie Schwingel,Marcello Sestu, Anna Burcza,Susanna Marg,Wolfgang Ziegler,Anna V. Taubenberger,Daniel J. Muller,Martin Bastmeyer,Clemens M. Franz
Journal of Molecular Recognitionno. 6 (2023): e3012-e3012
FRONTIERS IN PLANT SCIENCE (2023): 1228749-1228749
Giulia E M Ammirati, Michele Nava,Krishna Chaitanya Kasuba,Nico Strohmeyer,Jonne Helenius,Daniel Müller
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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