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Research Interests
Pharmacogenetic studies on the discovery of novel human genetic polymorphisms, their functional significance and their relationship to outcome of drug therapy, susceptibility to adverse drug reactions and susceptibility to complex diseases, especially those affecting the liver. These studies are central to the area of personalised (stratified) medicine and a key aim is to translate our findings to simple tests that can be used to determine the most appropriate drug treatment on an individual basis.
I coordinate the iDILIC network on genetics of drug-induced liver injury (see iDILIC Description) which is concerned with identifying genes relevant to drug-induced liver injury and also participate as the UNEW PI in the IMI-FP7-funded TransBioLine project which seeks to identify novel biomarkers for serious adverse drug reactions (https://transbioline.com/). I contribute to the LITMUS project (https://litmus-project.eu/) which is also IMI-FP7-funded and to the NIAAA-funded GenomALC (see GenomALC description). These studies are concerned with identification of biomarkers for non-alcoholic fatty liver disease (NAFLD) and for alcoholic liver cirrhosis respectively.
研究兴趣
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Tae-Hwi Schwantes-An,John B Whitfield,Guruprasad P Aithal, Stephen R Atkinson,Ramon Bataller, Greg Botwin,Naga P Chalasani,Heather J Cordell,Ann K Daly,Rebecca Darlay,Christopher P Day,Florian Eyer,
Hepatology communicationsno. 6 (2024)
Nehal Elmansoury, Ahmed A Megahed,Ahmed Kamal,Nefertiti El-Nikhely, Marina Labane, Manal Abdelmageed,Ann K Daly,Ahmed Wahid
Biochemical Pharmacologypp.116249-116249, (2024)
PHARMACOGENOMICSno. 5 (2023): 243-246
Mohammad A. Alshabeeb,Deemah Alwadaani, Farjah H. Al Qahtani,Salah Abohelaika,Mohsen Alzahrani, Abdullah Al Zayed,Hussain H. Al Saeed, Hala Al Ajmi, Barrak Alsomaie,Mamoon Rashid,Ann K. Daly
Nature metabolismno. 4 (2023): 572-578
Antibiotics (Basel, Switzerland)no. 3 (2023)
Frontiers in pharmacology (2023): 1189976
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