基本信息
浏览量:45
职业迁徙
个人简介
1997-2001 B.Sc. in Chemistry, Fudan University
2001-2005 Ph.D. in Biochemistry, Hong Kong University of Science and Technology (HKUST)
2005-2007 Postdoctoral Research Associate, Department of Biochemistry, HKUST
2007-2009 Research Assistant Professor, Department of Biochemistry, HKUST
2009- Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences
Research Interests
On the basis of NMR spectroscopy and X-ray crystallography, we focus on the structural and functional studies of protein complexes that are involved in the control of the cell polarity and molecular motors that play prominent roles in regulating intracellular transport.
1. Structural dissection of protein complexes involved in the control of cell polarity
Polarization of cells is a fundamental process vital for a variety of biological activities such as embryonic asymmetric cell division, epithelial differentiation, neuronal development, and cancer cell migration. Both establishment and maintenance of cell polarity are complicated processes and rigorously regulated by a number of protein complexes. These protein complexes are evolutionally conserved and restrictedly distributed at the specific cell cortex acting as hallmarks of cellular polarization. We focus on the structural and functional dissection of these protein complexes, and aim to investigate how these protein complexes assemble and what’s the biological significance for regulating cell polarity. The results of our research will provide mechanistic insights into the organization of cell polarity-regulatory protein complexes and may also hopefully generalize some rules for the establishment and maintenance of cell polarity.
2. Structural basis for molecular motor-mediated intracellular transport
Intracellular transport is a fundamental biological process responsible for delivering, exchanging, and recycling of biological materials within cells. Dysfunction of this process is coupled with a large number of pathological diseases. Molecular motors are cytoskeleton-based biological molecular machines capable of carrying cargo vesicles and walking along the cytoskeletons, and thus function as core components for intracellular transport. We work on the structural and functional studies of molecular motors, and are mainly interested in how the activity of molecular motors is exquisitely regulated in terms of the monomer-dimer conversion and the motor activation-inactivation. Our overall research will provide the molecular mechanism for the motor regulation and may also shed some light on molecular motor-mediated intracellular transport.
研究兴趣
论文共 158 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yongping Chai,Dong Li,Weibin Gong,Jingyi Ke, Dianzhe Tian,Zhe Chen, Angel Guo,Zhengyang Guo,Wei Li,Wei Feng,Guangshuo Ou
Proceedings of the National Academy of Sciences of the United States of Americano. 5 (2024)
VIRUSES-BASELno. 4 (2024): 541
Letao Li, Xilu Liu, Shanshan Yang,Meijiao Li,Yanwei Wu,Siqi Hu, Wenjuan Wang,Amin Jiang,Qianqian Zhang, Junbing Zhang, Xiaoli Ma, Junyan Hu, Qiaohong Zhao,Yubing Liu,Dong Li,Junjie Hu,Chonglin Yang,Wei Feng,Xiaochen Wang
Natureno. 8008 (2024): 1-9
The journal of cell biology/The Journal of cell biologyno. 9 (2024)
Biosensors and Bioelectronics (2024): 116429-116429
Angewandte Chemie (2024)
Chao Xie, Guanghan Chen,Ming Li, Peng Huang, Zhe Chen,Kexin Lei,Dong Li, Yuhe Wang,Augustine Cleetus,Mohamed A. A. Mohamed,Punam Sonar,Wei Feng,Zeynep Oekten,Guangshuo Ou
EMBO JOURNALno. 13 (2024): 2606-2635
加载更多
作者统计
#Papers: 158
#Citation: 6300
H-Index: 46
G-Index: 76
Sociability: 6
Diversity: 0
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn