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Christine Chio studies Pancreatic ductal adenocarcinoma (PDAC) that represents the third leading cause of cancer death in the United States. Lethality of PDA owes largely to the advanced disease stage at the time of diagnosis and to its profound resistance to existing therapies. Targeted therapy is a cornerstone of precision medicine, and is currently the focus of much anticancer drug development. However, in the context of pancreatic cancer, no chemical inhibitors exist for the most common KRAS mutations (G12D, G12V) even though it is well established that the oncogenic KRAS promotes drug resistance. Thus, a detailed understanding of the role of specific genetic lesions and their signaling surrogates in the initiation and progression of PDA is critical to improving treatment efficacy and patient outcome for this disease. Using genetically engineered mouse models and ex vivo culture systems, the Chio lab seeks to understand the basic mechanisms underlying PDAC biology such that vulnerabilities can be identified and tested for therapeutic intervention.
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论文共 44 篇作者统计合作学者相似作者
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Alison B. Ross, Darvesh Gorhe,Jenny Kim Kim,Stefanie Hodapp, Lela DeVine,Karina M. Chan,Iok In Christine Chio,Marko Jovanovic,Marina Ayres Pereira
Cell Reports Methodspp.100760-100760, (2024)
Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Yun Pyo Kang, Nicolas Prieto-Farigua,Justin R. Prigge,Edward E. Schmidt,Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Cancer Researchno. 7_Supplement (2023): 12-12
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Rebecca Boutin, Hiu-Fung Lee,Tian Lai Guan,Tan Trieu Nguyen,Xian Fang Huang,Daniel D. Waller, Jordan Lu,Iok In Christine Chio, Rene P. Michel,Michael Sebag,Youla S. Tsantrizos
JOURNAL OF MEDICINAL CHEMISTRYno. 23 (2023): 15776-15800
Royce Zhou, Jiangnan Xu,Tiphaine Martin,Alexis L. Zachem,John Z. He,Sait Öztürk,Deniz Demircioğlu, Ankita Bansal,Andrew P. Trotta,Bruno Giotti,Berkley E. Gryder,Yao Shen,
Cancer Researchno. 7_Supplement (2023): 3481-3481
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Justin A. Powers,Iok In Christine Chio
Kiyoshi Saeki,Wanglong Qiu,Richard A. Friedman, Samuel Pan, Jordan Lu, Shu Ichimiya,Iok In Christine Chio,Carrie J. Shawber,Jan Kitajewski,Jianhua Hu,Gloria H. Su
Dan He,Huijin Feng, Belen Sundberg,Jiaxing Yang, Justin Powers,Alec H Christian,John E Wilkinson,Cian Monnin,Daina Avizonis,Craig J Thomas,Richard A Friedman,Michael D Kluger,
Molecular cellno. 16 (2022): 3045-3060.e11
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