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We are interested in the plasticity of adult organs; how and why organs that we commonly regard as fully developed change in size or function in response to environmental or internal challenges.
We use the intestine and its neurons to explore these questions because they allow us to explore organ plasticity from an integrated perspective; how an organ senses and integrates signals from both its internal milieu and the environment (e.g. nutrients, microbiota), how its adult progenitors respond by either maintaining or resizing the organ, and how different cell types within the organ (epithelial, muscle, neural) communicate to achieve coordinated, organ-level remodelling.
We use the intestine and its neurons to explore these questions because they allow us to explore organ plasticity from an integrated perspective; how an organ senses and integrates signals from both its internal milieu and the environment (e.g. nutrients, microbiota), how its adult progenitors respond by either maintaining or resizing the organ, and how different cell types within the organ (epithelial, muscle, neural) communicate to achieve coordinated, organ-level remodelling.
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论文共 58 篇作者统计合作学者相似作者
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Development (Cambridge, England)no. 20 (2023)
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Emily Strachan,Irene Miguel-Aliaga
Natureno. 7962 (2023): 677-678
Nature Communicationsno. 1 (2023): 1-10
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Endocrine Abstracts (2022)
Cell metabolismno. 7 (2021): 1279-1292
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