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个人简介
The continued proliferation of human cells depends on the proper maintenance of the genomic information encoded in the 46 linear human chromosomes. The stability of these linear chromosomes depends on telomeres, which are maintained by telomerase.
Up-regulation of telomerase is found in more than 85% of human cancers, while telomerase insufficiency can cause early onset of human aging, highlighting the crucial role of telomerase regulation in both cancer therapy and human aging. On the one hand, we would like to inhibit overexpressed telomerase in tumor cells; on the other hand, we need to maintain the telomerase activity of normal stem cells to prevent early onset of aging.
My research goal is to elucidate mechanisms underlying the regulation of telomerase activity in cancer cells and normal stem cells, and to develop novel approaches for therapeutic intervention of human cancer and early onset of aging. Using both yeast and mammalian systems, I will focus on both (1) the regulation of telomerase activity by post-translational modification of telomerase and telomerase-related factors, and (2) the transcriptional regulation of human telomerase reverse transcriptase.
Up-regulation of telomerase is found in more than 85% of human cancers, while telomerase insufficiency can cause early onset of human aging, highlighting the crucial role of telomerase regulation in both cancer therapy and human aging. On the one hand, we would like to inhibit overexpressed telomerase in tumor cells; on the other hand, we need to maintain the telomerase activity of normal stem cells to prevent early onset of aging.
My research goal is to elucidate mechanisms underlying the regulation of telomerase activity in cancer cells and normal stem cells, and to develop novel approaches for therapeutic intervention of human cancer and early onset of aging. Using both yeast and mammalian systems, I will focus on both (1) the regulation of telomerase activity by post-translational modification of telomerase and telomerase-related factors, and (2) the transcriptional regulation of human telomerase reverse transcriptase.
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论文共 114 篇作者统计合作学者相似作者
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Akiko Niibori-Nambu,Chelsia Qiuxia Wang,Desmond Wai Loon Chin,Jing Yuan Chooi,Hiroki Hosoi, Takashi Sonoki,Cheng-Yong Tham,Giselle Sek Suan Nah, Branko Cirovic,Darren Qiancheng Tan,Hitoshi Takizawa, Goro Sashida,Yufen Goh, Jiaqi Tng,Wee Nih Fam,Melissa Jane Fullwood,Toshio Suda,Henry Yang,Vinay Tergaonkar, Ichiro Taniuchi,Shang Li,Wee Joo Chng,Motomi Osato
Gene (2024): 148761-148761
Chang Xu,Kie Kyon Huang,Jia Hao Law,Joy Shijia Chua,Taotao Sheng,Natasha M. Flores,Melissa Pool Pizzi,Atsushi Okabe,Angie Lay Keng Tan,Feng Zhu,Vikrant Kumar,Xiaoyin Lu,Ana Morales Benitez,Benedict Shi Xiang Lian,Haoran Ma,Shamaine Wei Ting Ho,Kalpana Ramnarayanan,Chukwuemeka George Anene-Nzelu,Milad Razavi-Mohseni,Siti Aishah Binte Abdul Ghani,Su Ting Tay,Xuewen Ong,Ming Hui Lee,Yu Amanda Guo,Hassan Ashktorab,Duane Smoot,Shang Li,Anders Jacobsen Skanderup,Michael A. Beer,Roger Sik Yin Foo, Joel Shi Hao Wong,Kaushal Sanghvi,Wei Peng Yong,Raghav Sundar,Atsushi Kaneda,Shyam Prabhakar,Pawel Karol Mazur,Jaffer A. Ajani,Khay Guan Yeoh,Jimmy Bok-Yan So,Patrick Tan
JAMA CARDIOLOGYno. 3 (2024): 305-305
crossref(2023)
Xiaosai Yao,Jing Han Hong,Amrita M. Nargund,Michelle Shu Wen Ng,Hong Lee Heng,Zhimei Li,Peiyong Guan,Masahiro Sugiura,Pek Lim Chu,Loo Chien Wang,Xiaofen Ye,James Qu,Xiu Yi Kwek,Jeffrey Chun Tatt Lim,Wen Fong Ooi,Joanna Koh,Zhenxun Wang,You-Fu Pan,Yan Shan Ong, Kiat-Yi Tan,Jian Yuan Goh,Sheng Rong Ng,Luca Pignata,Dachuan Huang,Alexander Lezhava,Su Ting Tay,Minghui Lee,Xun Hui Yeo,Wai Leong Tam,Sun Young Rha,Shang Li,Ernesto Guccione,Andrew Futreal,Jing Tan,Joe Poh Sheng Yeong,Wanjin Hong,Robert Yauch,Kenneth Tou-En Chang,Radoslaw M. Sobota,Patrick Tan,Bin Tean Teh
CANCER RESEARCHno. 7 (2023)
Jeremy Wee Kiat Ng, Kar Wai Tan, Dian Yan Guo,Joey Jia Hui Lai, Xiubo Fan,Zhiyong Poon,Tse Hui Lim,Alvin Soon Tiong Lim,Tony Kiat Hon Lim,William Ying Khee Hwang,Shang Li,Connie J. Eaves,Yeow Tee Goh,Alice Man Sze Cheung
Science Advancesno. 24 (2023)
Science advancesno. 24 (2023)
Meisam Yousefi,Wai Suet Lee,Wharton O. Y. Chan, Wei He,Marcus G. Mah,Cythia Lingli Yong,Joshua M. Deerain,Lijin Wang,Camille Arcinas,Biaoguo Yan,Dewei Tan,Wan Rong Sia,Akshamal M. Gamage,Jinxuan Yang,Alan Chen-Yu Hsu,Shang Li,Martin Linster,Xinglou Yang,Sujoy Ghosh,Danielle E. Anderson,Gavin J. D. Smith,Chee Wah Tan,Lin-Fa Wang,Yaw Shin Ooi
Amrita M Nargund,Chang Xu,Amit Mandoli,Atsushi Okabe,Gao Bin Chen,Kie Kyon Huang,Taotao Sheng,Xiaosai Yao,Jia Ming Nickolas Teo,Raghav Sundar,Yee Jiun Kok,Yi Xiang See,Manjie Xing,Zhimei Li,Chern Han Yong,Aparna Anand,Zul Fazreen Bin Adam Isa,Lai Fong Poon,Michelle Shu Wen Ng,Javier Yu Peng Koh,Wen Fong Ooi,Su Ting Tay,Xuewen Ong,Angie Lay Keng Tan,Duane T Smoot,Hassan Ashktorab,Heike I Grabsch,Melissa J Fullwood,Bin Tean Teh,Xuezhi Bi,Atsushi Kaneda,Shang Li,Patrick Tan
Cancer researchno. 5 (2023): 804-804
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作者统计
#Papers: 114
#Citation: 6634
H-Index: 36
G-Index: 81
Sociability: 6
Diversity: 4
Activity: 53
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