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Her research focus is on hematopoietic stem cell (HSC) biology and the development of human synthetic leukemia models to identify therapeutic vulnerabilities in high fatality pediatric leukemia. Long-lived HSC sustain the constant production of all mature cell lineages in the blood system, and constitute the critical cellular component of transplantation procedures performed in oncology for high risk malignancies, including leukemia. Nonetheless, factors that dictate HSC fate remain poorly defined, and their isolation and ex vivo culture remain challenging, limiting their clinical applications. The main focus of the laboratory is to study the role of chromatin methylation in human HSC biology. Accessibility of the transcriptional machinery to the genetic code is mediated through the concerted actions of chromatin modifying enzymes. The Mll (Mixed Lineage Leukemia) gene, encoding for a histone methyltransferase (of lysine 4 on histone 3, or H3K4) is involved in normal HSC maintenance and mutated in >70% of infant leukemia cases. Once thought to be irreversible, histone methylation is now regarded as a highly dynamic process, since the identification of the histone demethylase LSD1 (KDM1A) in 2004.
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BLOOD ADVANCESno. 1 (2024): 112-129
Journal of medical genetics (2023)
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Journal of Medical Geneticsno. 12 (2023): 1218-1223
Antoine Gourmel, Heloise Perrault,Marie-Laure Colaiacovo,Louise Laramee, Marieke Rozendaal,Henrique Bittencourt,Caroline Laverdiere, Josette Champagne,Sonia Cellot,Lewis B. Silverman,Emmanuelle Lemyre,Geraldine Mathonnet,
PEDIATRIC BLOOD & CANCER (2023): S151-S151
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Edith Sepulchre, Safa Jammali,Alexandre Rouette,Sylvie Langlois,Thomas Sontag,Chantal Richer, Billy Ta, Sami Ayachi,Loubna Jouan,Thai Hoa Tran,Daniel Sinnett, Catherine Goudie,
PEDIATRIC BLOOD & CANCER (2023)
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Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques,Safia Safa-Tahar-Henni, Eva Bresson,Anne Bergeron,Josée Hebert,Soheil Meshinchi,Sonia Cellot,Frédéric Barabé,Brian T Wilhelm
Gervaise Hubert,Henrique Bittencourt,Caroline Laverdière,Pierre Teira,Sonia Cellot,Sylvie Langlois,Alexandre Rouette,Thomas Sontag,Daniel Sinnett, Dorothée Dal-Soglio,Sophie Turpin,Thai Hoa Tran
Verena Gress,Sophie Cardin,Mathieu Roussy,Luc Boulianne,Furat Fatima,Louise Laramee, Emma Cheetham,Alexandre Rouette,Nehme Hachem,Melanie Bilodeau,Brian Wilhelm, Frederic Barabe,
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