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Research statement
My ultimate goal is to understand the the genomic changes that underlie vertebrate evolution and human disease. I use both computational genomics and experimental genetics to create a cycle where computational screens define promising candidates and follow-up wet-lab experiments provide feedback to improve the computational screens. By combining these approaches, I have: 1) shown that 20% of regulatory elements in the human genome arise from transposon insertions, 2) discovered three macroevolutionary epochs of gene regulatory innovation throghout vertebrate evolution, and 3) created statistical models to identify novel gene regulatory elements, including examples that relate to evolved human traits and increased disease risk. I will build on this previous work to systematically uncover how structural variation relates to evolution and disease risk through three major research directions:
1) Identifying species-specific structural variants in stickleback fish and humans, as well as understanding their function in development and evolution
2) Discovering novel structural variants segregating in humans and systematically analyzing their relationship to disease
3) Understanding the molecular basis of iconic traits that have arisen on branches of the vertebrate tree of life
Projects coming with me
1) New gene expression patterns in humans and their resulting phenotypic traits
2) Strongly selected deletions during stickleback evolution
My ultimate goal is to understand the the genomic changes that underlie vertebrate evolution and human disease. I use both computational genomics and experimental genetics to create a cycle where computational screens define promising candidates and follow-up wet-lab experiments provide feedback to improve the computational screens. By combining these approaches, I have: 1) shown that 20% of regulatory elements in the human genome arise from transposon insertions, 2) discovered three macroevolutionary epochs of gene regulatory innovation throghout vertebrate evolution, and 3) created statistical models to identify novel gene regulatory elements, including examples that relate to evolved human traits and increased disease risk. I will build on this previous work to systematically uncover how structural variation relates to evolution and disease risk through three major research directions:
1) Identifying species-specific structural variants in stickleback fish and humans, as well as understanding their function in development and evolution
2) Discovering novel structural variants segregating in humans and systematically analyzing their relationship to disease
3) Understanding the molecular basis of iconic traits that have arisen on branches of the vertebrate tree of life
Projects coming with me
1) New gene expression patterns in humans and their resulting phenotypic traits
2) Strongly selected deletions during stickleback evolution
研究兴趣
论文共 25 篇作者统计合作学者相似作者
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DongAhn Yoo,Arang Rhie, Prajna Hebbar,Francesca Antonacci,Glennis A Logsdon, Steven J Solar,Dmitry Antipov,Brandon D Pickett, Yana Safonova,Francesco Montinaro, Yanting Luo, Joanna Malukiewicz,Jessica M Storer,Jiadong Lin, Abigail N Sequeira, Riley J Mangan, Glenn Hickey, Graciela Monfort Anez,Parithi Balachandran, Anton Bankevich, Christine R Beck,Arjun Biddanda,Matthew Borchers, Gerard G Bouffard, Emry Brannan,Shelise Y Brooks,Lucia Carbone,Laura Carrel,Agnes P Chan, Juyun Crawford,Mark Diekhans,Eric Engelbrecht,Cedric Feschotte,Giulio Formenti, Gage H Garcia, Luciana de Gennaro,David Gilbert,Richard E Green,Andrea Guarracino, Ishaan Gupta,Diana Haddad, Junmin Han, Robert S Harris,Gabrielle A Hartley,William T Harvey, Michael Hiller,Kendra Hoekzema,Marlys L Houck,Hyeonsoo Jeong,Kaivan Kamali,Manolis Kellis,Bryce Kille,Chul Lee, Youngho Lee, William Lees,Alexandra P Lewis, Qiuhui Li,Mark Loftus, Yong Hwee Eddie Loh, Hailey Loucks,Jian Ma,Yafei Mao, Juan F I Martinez,Patrick Masterson,Rajiv C McCoy,Barbara McGrath, Sean McKinney, Britta S Meyer,Karen H Miga, Saswat K Mohanty,Katherine M Munson, Karol Pal, Matt Pennell, Pavel A Pevzner, David Porubsky,Tamara Potapova, Francisca R Ringeling,Joana L Rocha,Oliver A Ryder,Samuel Sacco, Swati Saha,Takayo Sasaki,Michael C Schatz, Nicholas J Schork, Cole Shanks,Linnéa Smeds, Dongmin R Son,Cynthia Steiner, Alexander P Sweeten,Michael G Tassia, Françoise Thibaud-Nissen,Edmundo Torres-González,Mihir Trivedi, Wenjie Wei, Julie Wertz,Muyu Yang, Panpan Zhang,Shilong Zhang,Yang Zhang, Zhenmiao Zhang, Sarah A Zhao, Yixin Zhu,Erich D Jarvis,Jennifer L Gerton,Iker Rivas-González,Benedict Paten,Zachary A Szpiech, Christian D Huber, Tobias L Lenz, Miriam K Konkel,Soojin V Yi, Stefan Canzar, Corey T Watson,Peter H Sudmant,Erin Molloy,Erik Garrison,Craig B Lowe,Mario Ventura, Rachel J O'Neill,Sergey Koren,Kateryna D Makova,Adam M Phillippy,Evan E Eichler
bioRxiv : the preprint server for biology (2024)
Luke C. Bartelt, Mouad Fakhri,Grazyna Adamek, Magdalena Trybus,Anna Samelak-Czajka,Paulina Jackowiak,Agnieszka Fiszer,Craig B. Lowe,Albert R. La Spada,Pawel M. Switonski
Cell Reports Methodsno. 7 (2024): 100816
Andrzej Dziembowski, Adam Mickiewicz,Marcin Drąg,Tomasz Piontek, Rossen Apostolov, The Cardinal, Luke C. Bartelt, Mouad Fakhri, Grażyna Adamek, Grzegorz Bartyzel, Michał Kurkowski, Magdalena Trybus,Anna Samelak-Czajka, Paulina Jackowiak,Agnieszka Fiszer,Craig B. Lowe, Albert La Spada, Paweł M. Świtoński,Katarzyna Klonowska,L Przybył, Magdalena Jazurek-Ciesiołka,Magdalena Woźna-Wysocka,Joanna Suszyńska-Zajczyk,Dorota Wronka, Julia O. Misiorek, Grzegorz Figura, Adam Ciesiołka, Paula Sobieszczańska,Maciej Figiel, Al Zeller,Magdalena Niemira
BioTechnologiano. 1 (2024): 97-104
bioRxiv the preprint server for biology (2023)
Eric H. Au,Christiana Fauci, Yanting Luo,Riley J. Mangan,Daniel A. Snellings,Chelsea R. Shoben, Seth Weaver, Shae K. Simpson,Craig B. Lowe
BIOINFORMATICSno. 8 (2023)
Riley J. Mangan,Fernando C. Alsina,Federica Mosti,Jesus Emiliano Sotelo-Fonseca,Daniel A. Snellings,Eric H. Au,Juliana Carvalho, Laya Sathyan, Graham D. Johnson,Timothy E. Reddy,Debra L. Silver,Craig B. Lowe
Alex A Pollen,Aparna Bhaduri,Madeline G Andrews,Tomasz J Nowakowski,Olivia S Meyerson,Mohammed A Mostajo-Radji,Elizabeth Di Lullo,Beatriz Alvarado, Melanie Bedolli,Max L Dougherty,Ian T Fiddes,Zev N Kronenberg,Joe Shuga,Anne A Leyrat,Jay A West,Marina Bershteyn,Craig B Lowe,Bryan J Pavlovic,Sofie R Salama,David Haussler,Evan E Eichler,Arnold R Kriegstein
semanticscholar(2018)
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作者统计
#Papers: 26
#Citation: 8649
H-Index: 15
G-Index: 19
Sociability: 6
Diversity: 2
Activity: 205
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