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We have developed a number of in vitro assays over the years that allow for the careful examination of the stages of B lineage development from multipotent stem cells to fully functional, antibody secreting, plasma cells. We have identified a number of key features and mechanisms of action that mark transitions between stages and defined checkpoints that can result in positive and negative selection. Amongst our current interest are: The role of the peptide, HK1 (a member of the tackykinin family) in regulating early events in the B lineage pool; a potential mechanism for abrogating IL7 responsiveness based on downstream induction of SOCS proteins; and a novel role for IL21 in accelerating B cell development. Out interest in these projects is driven not only by the desire to understand the role of these molecules in normal development but also because the aberrant regulation of any of these can have direct consequences in immune regulated disease.
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Cancer immunology, immunotherapy : CIIno. 8 (2023): 2597-2612
Cell reportsno. 10 (2020): 3448-3465.e8
The Journal of Immunologyno. 1_Supplement (2019): 71.11-71.11
SSRN Electronic Journal (2018)
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