基本信息
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职业迁徙
个人简介
Research Interests
Cancer Diagnosis and Therapy, Cancer Mechanisms and Models
Research Synopsis
Breast Cancer, Tumor Suppressors and Targeted Therapy
Our group employs molecular biology and mouse genetics to decipher mechanisms of cancer, in particular breast cancer, and identify dependencies that can be exploited for therapy. A major focus is the tumor suppressors RB1, PTEN and TP53. In breast cancer, one highly aggressive subtype, called triple negative breast cancer, is driven by mutation/loss of TP53 together with RB1 or PTEN. Our lab has generated mouse models in which p53/Rb or p53/Pten are deleted specifically in the mammary epithelium, and identified unique vulnerabilities of these tumors, as well as human breast cancer lines with mutations in these tumor suppressors. We are using transposon-mediated mutagenesis to identify oncogenic networks that cooperate with Rb and p53 to induce metastatic disease, and induce resistance to therapy. We are also studying the role of Rb is reprogramming cellular metabolism both in breast cancer and Medulloblastoma.
Cancer Diagnosis and Therapy, Cancer Mechanisms and Models
Research Synopsis
Breast Cancer, Tumor Suppressors and Targeted Therapy
Our group employs molecular biology and mouse genetics to decipher mechanisms of cancer, in particular breast cancer, and identify dependencies that can be exploited for therapy. A major focus is the tumor suppressors RB1, PTEN and TP53. In breast cancer, one highly aggressive subtype, called triple negative breast cancer, is driven by mutation/loss of TP53 together with RB1 or PTEN. Our lab has generated mouse models in which p53/Rb or p53/Pten are deleted specifically in the mammary epithelium, and identified unique vulnerabilities of these tumors, as well as human breast cancer lines with mutations in these tumor suppressors. We are using transposon-mediated mutagenesis to identify oncogenic networks that cooperate with Rb and p53 to induce metastatic disease, and induce resistance to therapy. We are also studying the role of Rb is reprogramming cellular metabolism both in breast cancer and Medulloblastoma.
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