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My previous work demonstrated that specific immune cells, monocytes, in the blood of chronic hepatitis B patients internalize and retain viral antigen. Using a combination of cytokines we could stimulate presentation of the captured antigen to boost HBV-specific T cell immunity. The goal now is to further understand this mechanism in patients to define an immunotherapeutic drug combination that can be used to restore anti-viral T cell immunity using the personalized antigen reservoir in the patients’ blood.
Our research on human liver immunology focuses on how age, sex and infection impact the intrahepatic immune response. Chronic hepatitis B is a progressive disease that worsens with age and men are more likely than women to develop liver cancer. We are trying to elucidate functional differences in the liver to understand HBV progression and biomarkers that could provide a drug targets to stop or slow disease progression.
Our research on human liver immunology focuses on how age, sex and infection impact the intrahepatic immune response. Chronic hepatitis B is a progressive disease that worsens with age and men are more likely than women to develop liver cancer. We are trying to elucidate functional differences in the liver to understand HBV progression and biomarkers that could provide a drug targets to stop or slow disease progression.
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论文共 138 篇作者统计合作学者相似作者
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Sergi Clotet-Freixas, Olga Zaslaver,Max Kotlyar, Chiara Pastrello,Andrew T. Quaile, Caitriona M. McEvoy, Aninda D. Saha,Sofia Farkona, Alex Boshart, Katarina Zorcic, Slaghaniya Neupane, Kieran Manion,
biorxiv(2024)
Muhammad Atif Zahoor, Joshua B Feld,Hsing-Hua Sylvia Lin, Alexander I Mosa, Loghman Salimzadeh,Robert P Perrillo,Raymond T Chung,Kathleen B Schwarz,Harry LA Janssen,Adam J Gehring,Jordan J Feld
Hepatology (Baltimore, Md.) (2024)
Adam J. Gehring, Loghman Salimzadeh
Antiviral Researchpp.105893, (2024)
Journal of immunology (Baltimore, Md. : 1950)no. 6 (2024): 1002-1011
Tallulah S Andrews,Diana Nakib,Catia T Perciani,Xue Zhong Ma,Lewis Liu,Erin Winter,Damra Camat,Sai W Chung, Patricia Lumanto,Justin Manuel, Shantel Mangroo,Bettina Hansen,
Journal of hepatology (2024)
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bioRxiv : the preprint server for biology (2023)
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