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个人简介
I study drug compound permeation across biological barriers and the interplay with transport proteins to improve our understanding of these barriers and how they can be overcome through drug delivery.
My research is mainly focused on the blood-brain barrier and the role of efflux transporters. To this end, we develop cell culture models that mimick the human blood-brain barrier or over-express efflux transport proteins using human stem cells or immortalized cell lines. We use these cell models to study the dynamics of substrate-transporter interactions and explore new drug delivery concepts to improve brain delivery.
My research is mainly focused on the blood-brain barrier and the role of efflux transporters. To this end, we develop cell culture models that mimick the human blood-brain barrier or over-express efflux transport proteins using human stem cells or immortalized cell lines. We use these cell models to study the dynamics of substrate-transporter interactions and explore new drug delivery concepts to improve brain delivery.
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Amanda Kongstad Redke Nielsen, Laura Lilieholm-Rongren,Benjamin Schmid,Bjorn Holst, Birger Brodin,Lasse Saaby
Fluids and Barriers of the CNSno. 1 (2024): 1-15
Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg,Burak Ozgür,Lasse Saaby,Christoffer Bundgaard,Mie Kristensen,Peer Tfelt-Hansen,Birger Brodin
Fluids and Barriers of the CNSno. 1 (2024): 1-19
Janni Stovring Mortensen,Soren S. -R. Bohr, Lasse Skjoldborg Krog,Johan Peter Botker, Vaya Kapousidou,Lasse Saaby,Nikos S. Hatzakis,Hanne Morck Nielsen,Duc Ninh Nguyen,Stine Ronholt
SCIENTIFIC REPORTSno. 1 (2024): 7665-7665
Troels Ronco, Line H Kappel,Maria F Aragao, Niccolo Biagi,Søren Svenningsen,Jørn B Christensen,Anders Permin,Lasse Saaby,Kim Holmstrøm,Janne K Klitgaard,Artur J Sabat,Viktoria Akkerboom,
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