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fter developing and validating accurate techniques to assess changes in cardiac myocyte shape and number, Martin Gerdes, Ph.D., defined how these cells remodel in physiological and pathological conditions. He demonstrated that the dilated, thin-walled ventricle characteristic of systolic heart failure was due to a maladaptive change in myocyte shape (increased length with no change in diameter) rather than slippage of myocytes past each other. In addition, Gerdes showed that chronic hypothyroidism alone can eventually lead to dilated heart failure with a maladaptive change in myocyte shape and impaired coronary blood flow. His research has shown that serum thyroid hormone levels may underestimate the true incidence of low cardiac tissue hormones in heart disease.
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Journal of molecular and cellular cardiology (2022): 24-25
Thyroid and Heartpp.137-152, (2020)
Kaihao Wang,Kaie Ojamaa, Abigail Samuels,Nimra Gilani,Kuo Zhang,Shimin An,Youhua Zhang,Yi-Da Tang, Bardia Askari,Anthony Martin Gerdes
HEART RHYTHM O2no. 2 (2020): 126-135
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