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Micro-and Nanometer-Scale Chemical Manipulation and Analysis:
My group works at the interface between chemistry, engineering and biology. Thus, students receive broad technical training and are well poised to contribute in these key research fields. A common theme in my research is the interrelationship between biological molecules and miniaturization. We are utilizing miniaturization tools to detect and quantify clinically relevant biomolecules, and we are also applying DNA in forming nanoscale materials.
A. Integrated microfluidic systems for preterm birth risk assessment. Preterm birth (PTB) is a serious issue, with approximately 10% of pregnancies resulting in a preterm delivery, frequently coupled with complications that lead to poor outcomes and increased medical costs. We are developing microfluidic systems that combine extraction, fluorescent labeling and separation all in a single microchip (Fig. 1). These devices will provide high-throughput, point of care screening from a finger stick quantity of blood to assess risk of a preterm delivery, weeks before contractions begin.
B. Biotemplated nanofabrication of electronics: My group is leading an interdisciplinary team whose objective is to explore bottom-up methods for the fabrication of nanoscale electronic systems. We fold DNA into controlled nanoscale designs that can be converted into functional electronic elements after purification and metallization (Fig. 2). We are presently applying these methods in making metal-semiconductor junctions with linewidths as small as 5 nm.
C. Low-cost microfluidic systems for rapid biomarker quantitation. We are developing simple, detectorless microfluidic systems for rapid analyte quantitation in resource-limited settings. These “flow valve” microdevices utilize capillary flow of solution and constrict in response to a target analyte (Fig. 3). The flow distance, which can be easily measured by simple visual inspection, can thus tell us the risk of a concentration of target molecule in the solution.
My group works at the interface between chemistry, engineering and biology. Thus, students receive broad technical training and are well poised to contribute in these key research fields. A common theme in my research is the interrelationship between biological molecules and miniaturization. We are utilizing miniaturization tools to detect and quantify clinically relevant biomolecules, and we are also applying DNA in forming nanoscale materials.
A. Integrated microfluidic systems for preterm birth risk assessment. Preterm birth (PTB) is a serious issue, with approximately 10% of pregnancies resulting in a preterm delivery, frequently coupled with complications that lead to poor outcomes and increased medical costs. We are developing microfluidic systems that combine extraction, fluorescent labeling and separation all in a single microchip (Fig. 1). These devices will provide high-throughput, point of care screening from a finger stick quantity of blood to assess risk of a preterm delivery, weeks before contractions begin.
B. Biotemplated nanofabrication of electronics: My group is leading an interdisciplinary team whose objective is to explore bottom-up methods for the fabrication of nanoscale electronic systems. We fold DNA into controlled nanoscale designs that can be converted into functional electronic elements after purification and metallization (Fig. 2). We are presently applying these methods in making metal-semiconductor junctions with linewidths as small as 5 nm.
C. Low-cost microfluidic systems for rapid biomarker quantitation. We are developing simple, detectorless microfluidic systems for rapid analyte quantitation in resource-limited settings. These “flow valve” microdevices utilize capillary flow of solution and constrict in response to a target analyte (Fig. 3). The flow distance, which can be easily measured by simple visual inspection, can thus tell us the risk of a concentration of target molecule in the solution.
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Analytica chimica acta (2024): 342338-342338
Analytical and bioanalytical chemistryno. 9 (2024): 2001-2003
Matthew S Viglione, Aubrianna Saxton, Dawson Downs,Adam T Woolley,Kenneth A Christensen,Pam M Van Ry, Gregory P Nordin
Lab on a Chip (2024)
MICROMACHINESno. 7 (2023): 1286-1286
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Analytical and Bioanalytical Chemistryno. 10 (2023): 1787-1789
Jacob B. Nielsen, James D. Holladay, Addalyn J Burningham,Naomi Rapier-Sharman, Joshua S. Ramsey, Timothy B. Skaggs,Gregory P. Nordin,Brett E. Pickett,Adam T. Woolley
Analytical and Bioanalytical Chemistryno. 29-30 (2023): 7057-7065
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