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In 2010 I took up a new Chair in Paediatric Science at the University of Manchester.
I am also an Honorary Consultant in Paediatric Nephrology in the Royal Manchester Children's Hospital.
Previously, in 1998, I established an academic centre for Nephrology and Urology at the UCL Institute of Child Health, London, which I headed until the end of 2009.
A main research aim is to find out why people are sometimes born with abnormal kidneys, ureters and bladders. These are the key causes of children needing long term renal dialysis and kidney transplantation. I am also working on translational therapies, including those based on growth factors and precursor cells, for kidney, bladder and, more recently, neural disease.
My research successes include: discovery of mutations in kidney and urinary tract malformations, and showing that the encoded molecules regulate epithelial, smooth muscle and neural differentiation; elucidating and ameliorating pathological mesenchymal-epithelial growth factor signalling in the renal tract and also the peritoneal lining; testing preclinical growth factor therapies for polycystic kidney diseases and renal agenesis; and using human pluripotent stem cell models to model normal and abnormal renal tract development.
My research and development work unites speciality clinical services with new perspectives from Developmental, Cell Biology and Genomic sciences. I have published 165 original research publications, with 'h' and 'g' factors of 63 and 101 (Google Scholar).
I have supervised clinical and science students leading to 19 PhD, three MD, 11 MRes, two MSc and one MPhil awarded theses. I currently supervise three PhD students and one MRes student.
Of my ex-students: two are full Professors and one is an Associate Professor (all at UCL); two others became a Lecturers (UCL and UoM); one is a research associate at University of Cambridge; and one is a Senior Lecturer (Chester University). Of postdoctoral researchers I supervised, one is Associate Professor (University of Nottingham), two are Lecturers (Universities of Nottingham and Salford), another became a Lecturer and founded a Bio-Tech company (UCL and Angio-Proteomie), and one became a Kidney Research UK Fellow (UoM).
In 2015, The Renal Association gave me their Lockwood Award, and I was their 2016 de Wardener Lecturer, both in recognition of my outstanding record in research and teaching.
From 2006-2009 I undertook a clinic at Great Ormond Street Hospital, London, focusing on renal tract malformations, which had an impact on diagnosis of these conditions and genetic counseling. With clinical genetics and adult nephrology colleagues, I established a similar clinic in the Royal Manchester Children's Hospital in 2010. In 2012, we established another clinic, in St Mary's Hospital, to assess adults with a family history of kidney disease.
I was a Trustee and Honorary Secretary of The Renal Association (2000-2004). I was the Research Secretary of the British Association for Paediatric Nephrology (2000-2002). I served on the National Kidney Research Fund grants committee (1997-2002). I was a Trustee of Kidney Research UK (2012-2018), with special remits leading their Research Career Development programme and chairing their Research Strategy Committee.
I am also an Honorary Consultant in Paediatric Nephrology in the Royal Manchester Children's Hospital.
Previously, in 1998, I established an academic centre for Nephrology and Urology at the UCL Institute of Child Health, London, which I headed until the end of 2009.
A main research aim is to find out why people are sometimes born with abnormal kidneys, ureters and bladders. These are the key causes of children needing long term renal dialysis and kidney transplantation. I am also working on translational therapies, including those based on growth factors and precursor cells, for kidney, bladder and, more recently, neural disease.
My research successes include: discovery of mutations in kidney and urinary tract malformations, and showing that the encoded molecules regulate epithelial, smooth muscle and neural differentiation; elucidating and ameliorating pathological mesenchymal-epithelial growth factor signalling in the renal tract and also the peritoneal lining; testing preclinical growth factor therapies for polycystic kidney diseases and renal agenesis; and using human pluripotent stem cell models to model normal and abnormal renal tract development.
My research and development work unites speciality clinical services with new perspectives from Developmental, Cell Biology and Genomic sciences. I have published 165 original research publications, with 'h' and 'g' factors of 63 and 101 (Google Scholar).
I have supervised clinical and science students leading to 19 PhD, three MD, 11 MRes, two MSc and one MPhil awarded theses. I currently supervise three PhD students and one MRes student.
Of my ex-students: two are full Professors and one is an Associate Professor (all at UCL); two others became a Lecturers (UCL and UoM); one is a research associate at University of Cambridge; and one is a Senior Lecturer (Chester University). Of postdoctoral researchers I supervised, one is Associate Professor (University of Nottingham), two are Lecturers (Universities of Nottingham and Salford), another became a Lecturer and founded a Bio-Tech company (UCL and Angio-Proteomie), and one became a Kidney Research UK Fellow (UoM).
In 2015, The Renal Association gave me their Lockwood Award, and I was their 2016 de Wardener Lecturer, both in recognition of my outstanding record in research and teaching.
From 2006-2009 I undertook a clinic at Great Ormond Street Hospital, London, focusing on renal tract malformations, which had an impact on diagnosis of these conditions and genetic counseling. With clinical genetics and adult nephrology colleagues, I established a similar clinic in the Royal Manchester Children's Hospital in 2010. In 2012, we established another clinic, in St Mary's Hospital, to assess adults with a family history of kidney disease.
I was a Trustee and Honorary Secretary of The Renal Association (2000-2004). I was the Research Secretary of the British Association for Paediatric Nephrology (2000-2002). I served on the National Kidney Research Fund grants committee (1997-2002). I was a Trustee of Kidney Research UK (2012-2018), with special remits leading their Research Career Development programme and chairing their Research Strategy Committee.
研究兴趣
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Nature Communicationsno. 1 (2024): 1-29
PEDIATRIC NEPHROLOGY (2023): S79-S79
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Kidney International Reportsno. 7 (2023): 1417-1429
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TISSUE ENGINEERING PART Ano. 13-14 (2023)
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EUROPEAN JOURNAL OF HUMAN GENETICS (2023): 516-517
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