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The Ensminger lab is interested in the evolution of microbial pathogens and the mechanisms by which these diminutive organisms persist in our environment and make us sick.
We focus our attention primarily on Legionella pneumophila, a remarkable bacterial pathogen that maintains the microbial world’s largest known arsenal of translocated effectors (with over 300 identified to date). Unlocking the secrets of this arsenal holds immense promise to provide novel insight into fundamental eukaryotic pathways, human health, and disease.
We use a variety of approaches in the lab, from advanced sequencing technologies (Illumina, Pacific Biosciences), bioinformatics, microbial genetics, high-throughput genetic and chemogenetic screening, and experimental evolution.
We focus our attention primarily on Legionella pneumophila, a remarkable bacterial pathogen that maintains the microbial world’s largest known arsenal of translocated effectors (with over 300 identified to date). Unlocking the secrets of this arsenal holds immense promise to provide novel insight into fundamental eukaryotic pathways, human health, and disease.
We use a variety of approaches in the lab, from advanced sequencing technologies (Illumina, Pacific Biosciences), bioinformatics, microbial genetics, high-throughput genetic and chemogenetic screening, and experimental evolution.
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论文共 43 篇作者统计合作学者相似作者
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Malene L. Urbanus, Thomas M. Zheng,Anna N. Khusnutdinova, Doreen Banh, Harley O’Connor Mount, Alind Gupta, Peter J. Stoigos,Alexei Savchenko,Ralph R. Isberg, Alexander F. Yakunin,Alexander W. Ensminger
crossref(2024)
Senjuti Saha,Chidozie D. Ojobor, Annie Si Cong Li, Erik Mackinnon,Olesia I. North,Joseph Bondy-Denomy,Joseph S. Lam,Alexander W. Ensminger,Karen L. Maxwell,Alan R. Davidson
JOURNAL OF BACTERIOLOGYno. 6 (2023)
mBiono. 5 (2023): e0151023-e0151023
Jordan D. Lin,Peter J. Stogios,Kento T. Abe, Avril Wang, John MacPherson,Tatiana Skarina,Anne-Claude Gingras,Alexei Savchenko,Alexander W. Ensminger
MBIOno. 5 (2023)
biorxiv(2022)
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