基本信息
浏览量:131
职业迁徙
个人简介
Research Interests
We are interested in the molecular basis of cell death and proliferation control during the genotoxic stress response. Our laboratory is primarily using two human tumor models: (i) Chronic lymphocytic leukemia (CLL) for leukemia, and (ii) prostate cancer, for epithelial tumors. For leukemia, we seek to understand therapeutic resistance and how the BCL-2 family and autophagy regulation contributes to it. Overcoming such resistance with rational, targeted approaches, is a desired outcome for translation of these findings into clinical setting. Specifically: 1) We study the role of BCL-xL and MCL-1 in resistance to and sensitization to BCL-2 homology domain 3 (BH3) mimetics, 2) We study autophagy as a mechanism of resistance, and 3) We seek to lay the foundations for optimizing the use of BCL-2 targeting agents by integrating gene expression data obtained from cell lines with that from patients treated in the clinic or ex vivo. Understanding the critical BCL-2 family protein associations according to differing cell sensitivities will allow development of molecular and pharmacologic approaches for their effective targeting. We recently identified a previously unexplored connection between autophagy and DNA damage response, via the deubiquitinase USP14. We are now extending the role of USP14 in DNA repair and immunity. By characterizing apoptotic and autophagy pathways in lymphoid malignancies, we seek to ultimately use them to predict response and thus personalize the selection of targeted therapeutic agents. For prostate, we are pursuing in addition to similar studies in autophagy also how it impact on repair of DNA damage, and ultimately to the outcome of radiotherapy. We seek to understand the DNA damage signals incurred by mammalian cells following ionizing radiation (IR). We are interested in IR-regulated genes, with a focus on those that have an important role in cell cycle checkpoints, cell proliferation, apoptosis (Bcl-2 family), and autophagy (ATG family, Beclin, mTOR). A third project focuses on a tumor-specific cell death ligand,Apo2L/TRAIL and its role in apoptosis, autophagy and potential for cancer therapy.
We are interested in the molecular basis of cell death and proliferation control during the genotoxic stress response. Our laboratory is primarily using two human tumor models: (i) Chronic lymphocytic leukemia (CLL) for leukemia, and (ii) prostate cancer, for epithelial tumors. For leukemia, we seek to understand therapeutic resistance and how the BCL-2 family and autophagy regulation contributes to it. Overcoming such resistance with rational, targeted approaches, is a desired outcome for translation of these findings into clinical setting. Specifically: 1) We study the role of BCL-xL and MCL-1 in resistance to and sensitization to BCL-2 homology domain 3 (BH3) mimetics, 2) We study autophagy as a mechanism of resistance, and 3) We seek to lay the foundations for optimizing the use of BCL-2 targeting agents by integrating gene expression data obtained from cell lines with that from patients treated in the clinic or ex vivo. Understanding the critical BCL-2 family protein associations according to differing cell sensitivities will allow development of molecular and pharmacologic approaches for their effective targeting. We recently identified a previously unexplored connection between autophagy and DNA damage response, via the deubiquitinase USP14. We are now extending the role of USP14 in DNA repair and immunity. By characterizing apoptotic and autophagy pathways in lymphoid malignancies, we seek to ultimately use them to predict response and thus personalize the selection of targeted therapeutic agents. For prostate, we are pursuing in addition to similar studies in autophagy also how it impact on repair of DNA damage, and ultimately to the outcome of radiotherapy. We seek to understand the DNA damage signals incurred by mammalian cells following ionizing radiation (IR). We are interested in IR-regulated genes, with a focus on those that have an important role in cell cycle checkpoints, cell proliferation, apoptosis (Bcl-2 family), and autophagy (ATG family, Beclin, mTOR). A third project focuses on a tumor-specific cell death ligand,Apo2L/TRAIL and its role in apoptosis, autophagy and potential for cancer therapy.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn