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The research activities in the Wodarz laboratory focus mainly on different aspects of the asymmetric division of neural stem cells. Asymmetric cell division is a fundamental mechanism for the generation of cell diversity in complex organisms. At the same time, asymmetric cell division is essential for the balance between stem cells and differentiating cells in an organism. Disturbances of this balance can cause severe diseases, including cancer and neurodevelopmental disorders. Asymmetric cell division is intricately linked to the control of apical-basal cell polarity, which is investigated in a second research focus. The establishment and maintenance of apical-basal cell polarity is connected to the regulation of planar cell polarity (PCP) and cell adhesion, especially in epithelial tissues. In this context, we investigate the function of the evolutionarily conserved Wnt signal transduction pathway in the regulation of PCP and cell adhesion.
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论文共 107 篇作者统计合作学者相似作者
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Parisa Kakanj, Mari Bonse, Aylin Gökmen,Felix Gaedke, Belén Mollá,Elisabeth Vogelsang,Astrid Schauss,Andreas Wodarz,David Pla-Martín
biorxiv(2024)
crossref(2024)
biorxiv(2023)
Galyna Pryymachuk,Ehab El-Awaad, Nadin Piekarek,Uta Drebber,Alexandra C. Maul, Juergen Hescheler,Andreas Wodarz,Gabriele Pfitzer,Wolfram F. Neiss,Markus Pietsch,Mechthild M. Schroeter
Karen Linnemannstöns,Leonie Witte,Pradhipa Karuna, Jeanette Kittel,Adi Danieli, Denise Müller,Lena Nitsch,Mona Honemann-Capito,Ferdinand Grawe,Andreas Wodarz,Julia Christina Gross
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