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个人简介
Research summary
My principal area of research is visual psychophysics, within which my specializations include colour vision, rod vision, visual adaptation, temporal sensitivity and clinical vision. A particular focus is the unravelling of the mechanisms and postreceptoral circuits that underlie normal and abnormal human vision and visual processing. In general, I try to relate my psychophysical work to the underlying physiology and anatomy, both in terms of the design of the experiments and in terms of the resulting models.
Perhaps my best known research is that on human spectral sensitivities. The “Stockman & Sharpe” cone spectral sensitivities and the related luminous efficiency functions, all based on measurements in observers of known photopigment opsin genotype, have now been adopted by the Commission Internationale de l'Éclairage (CIE) as a new international standard for colour definition and colour measurement.
Other important work, much of which is ongoing, includes measurements of cone and rod temporal (flicker) sensitivity and delay that have resulted in the identification of “slow” and “fast” signals in photopic and mesopic vision, the discovery of an unexpected S-cone input to luminance, and models of rod and cone adaptation. Measurements of the visible distortion that accompanies flicker has allowed the processing of the visual system to be dissected into early and late stages. In three recent papers stemming from this work, we have modelled the properties of the common pathway that we believe is responsible for colour and brightness perception. Another ongoing project investigates how chromatic signals are processed and in particular why chromatic signals are processed much more slowly than achromatic ones. A new area of research is that of Adaptive Optics (AO). We will design and build a user-friendly, AO visual stimulator with which to simultaneously image the retina at high resolution and to present high-resolution visual stimuli (such as gratings). This will allow us to generate coloured images with high temporal and spatial resolution over an extended intensity range. Once constructed, we will carry out a series of fundamental measurements of human visual performance. We will determine the human spatial contrast sensitivity functions (CSFs) for detecting achromatic, chromatic, and L-, M- and S-cone-isolating stimuli in the absence of the limitations normally imposed by the optics of the eye
Although my main research focus has been concerned with basic (non-clinical) research, I have become increasingly interested in and involved with the investigation of various clinical visual disorders, many of which result from mutations in genes that encode proteins essential for retinal visual function. We use psychophysical tools to characterize visual losses in patients suffering from mutations that cause, for example, rod monochromatism, retinitis pigmentosa, cone and cone-rod dystrophies, Bradyopsia, S-cone monochromatism, cone dystrophy with super-normal rod responses, stationary night blindness, oligocone trichromacy, congenital stationary night blindness, and enhanced S-cone syndrome.
My principal area of research is visual psychophysics, within which my specializations include colour vision, rod vision, visual adaptation, temporal sensitivity and clinical vision. A particular focus is the unravelling of the mechanisms and postreceptoral circuits that underlie normal and abnormal human vision and visual processing. In general, I try to relate my psychophysical work to the underlying physiology and anatomy, both in terms of the design of the experiments and in terms of the resulting models.
Perhaps my best known research is that on human spectral sensitivities. The “Stockman & Sharpe” cone spectral sensitivities and the related luminous efficiency functions, all based on measurements in observers of known photopigment opsin genotype, have now been adopted by the Commission Internationale de l'Éclairage (CIE) as a new international standard for colour definition and colour measurement.
Other important work, much of which is ongoing, includes measurements of cone and rod temporal (flicker) sensitivity and delay that have resulted in the identification of “slow” and “fast” signals in photopic and mesopic vision, the discovery of an unexpected S-cone input to luminance, and models of rod and cone adaptation. Measurements of the visible distortion that accompanies flicker has allowed the processing of the visual system to be dissected into early and late stages. In three recent papers stemming from this work, we have modelled the properties of the common pathway that we believe is responsible for colour and brightness perception. Another ongoing project investigates how chromatic signals are processed and in particular why chromatic signals are processed much more slowly than achromatic ones. A new area of research is that of Adaptive Optics (AO). We will design and build a user-friendly, AO visual stimulator with which to simultaneously image the retina at high resolution and to present high-resolution visual stimuli (such as gratings). This will allow us to generate coloured images with high temporal and spatial resolution over an extended intensity range. Once constructed, we will carry out a series of fundamental measurements of human visual performance. We will determine the human spatial contrast sensitivity functions (CSFs) for detecting achromatic, chromatic, and L-, M- and S-cone-isolating stimuli in the absence of the limitations normally imposed by the optics of the eye
Although my main research focus has been concerned with basic (non-clinical) research, I have become increasingly interested in and involved with the investigation of various clinical visual disorders, many of which result from mutations in genes that encode proteins essential for retinal visual function. We use psychophysical tools to characterize visual losses in patients suffering from mutations that cause, for example, rod monochromatism, retinitis pigmentosa, cone and cone-rod dystrophies, Bradyopsia, S-cone monochromatism, cone dystrophy with super-normal rod responses, stationary night blindness, oligocone trichromacy, congenital stationary night blindness, and enhanced S-cone syndrome.
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期刊级别
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Optics Express (2024)
COLOR RESEARCH AND APPLICATION (2024)
Color Research and Applicationno. 3 (2023): 255-255
COLOR RESEARCH AND APPLICATIONno. 3 (2023): 255-255
COLOR RESEARCH AND APPLICATIONno. 6 (2023): 818-840
Color and Imaging Conferenceno. 1 (2023): 20-25
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