基本信息
浏览量:5
职业迁徙
个人简介
Research summary
CD4+ Regulatory T cells (Tregs) are crucial to maintain tolerance, balancing effector T cell responses to harmful agents and suppressing unwanted responses. However, too little control may lead to autoimmunity (e.g. juvenile idiopathic arthritis or type 1 diabetes), while too much control may contribute to the development of cancers. Co-stimulatory and co-inhibitory receptors are crucial to determine functional outcomes upon activation. We found an imbalance of co-receptor expression at the site of inflammation and mutations in co-receptor genes have been associated with autoimmunity.
We focus on the co-receptor family CD226, TIGIT and CD96; receptors highly expressed on Tregs but with little understanding of their function. We use cellular and molecular immunology techniques, including the cutting-edge gene-editing system CRISPR-Cas9, to elucidate the CD226, TIGIT and CD96 signalling, receptor-receptor and receptor-ligand interactions and study their role in primary human Treg function in health and disease.
CD4+ Regulatory T cells (Tregs) are crucial to maintain tolerance, balancing effector T cell responses to harmful agents and suppressing unwanted responses. However, too little control may lead to autoimmunity (e.g. juvenile idiopathic arthritis or type 1 diabetes), while too much control may contribute to the development of cancers. Co-stimulatory and co-inhibitory receptors are crucial to determine functional outcomes upon activation. We found an imbalance of co-receptor expression at the site of inflammation and mutations in co-receptor genes have been associated with autoimmunity.
We focus on the co-receptor family CD226, TIGIT and CD96; receptors highly expressed on Tregs but with little understanding of their function. We use cellular and molecular immunology techniques, including the cutting-edge gene-editing system CRISPR-Cas9, to elucidate the CD226, TIGIT and CD96 signalling, receptor-receptor and receptor-ligand interactions and study their role in primary human Treg function in health and disease.
研究兴趣
论文共 40 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Meryl H Attrill, Diana Shinko, Telma Martins Viveiros, Martina Milighetti, Nina M Gruijter,Bethany Jebson,Melissa Kartawinata,Elizabeth C Rosser,Lucy R Wedderburn,Anne M Pesenacker
crossref(2024)
F. Chang,A. Vaitkute,M. Attrill, S. Chong,H. Mahdi,P. Blair,A. Salama,C. Mauri,S. Eaton, M. Bajaj-Elliott,A. Pesenacker,R. Motallebzadeh
BRITISH JOURNAL OF SURGERYno. Supplement_3 (2023)
T. Fox,B. Houghton,L. Petersone,E. Waters,N. Edner, A. Mckenna,O. Preham,C. Hinze,C. Williams, A. Albuquerque, A. Kennedy,A. Pesenacker,
Meryl H Attrill, Diana Shinko, Vicky Alexiou,Melissa Kartawinata,Lucy R Wedderburn, CHARMS study, JIAP study,Anne M Pesenacker
biorxiv(2023)
引用0浏览0引用
0
0
Immunotherapy advancesno. 1 (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn