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Pathophysiology of Neurodegeneration: Molecular and cellular Biology
Overview: The goal of our research is to understand the mechanisms underlying neurodegenerative diseases, and then to use this understanding to develop novel interventions for disease. Much of our research focuses on the central concept of regulated protein aggregation. Protein aggregation in neurodegenerative diseases is classically thought to occur as an unwanted byproduct of protein misfolding. Human genetic studies increasingly highlight the importance of RNA binding proteins in neurodegenerative diseases. This is important because RNA binding proteins use protein aggregation as part of a normal regulated, physiological mechanism controlling protein synthesis. Aggregated RNA binding proteins for stress granules, transport granules, P bodies, as well as participate in physiological functions, such as activity dependent protein synthesis. Our research investigates the hypothesis that dysfunction of RNA granules causes neurodegenerative diseases. Over active stress granule formation could contribute to neurodegeneration by altering patterns of protein synthesis and sequestering proteins that regulate cell death processes. Hypo-active stress granules, leads to inadequate neuroprotection.
研究兴趣
论文共 276 篇作者统计合作学者相似作者
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Lulu Jiang, Rebecca Roberts,Melissa Wong,Lushuang Zhang,Chelsea Joy Webber,Jenna Libera,Zihan Wang,Alper Kilci,Matthew Jenkins,Alejandro Rondon Ortiz,Luke Dorrian,Jingjing Sun,Guangxin Sun,Sherif Rashad,Caroline Kornbrek,Sarah Anne Daley,Peter C. Dedon, Brian Nguyen,Weiming Xia,Takashi Saito,Takaomi C. Saido,Benjamin Wolozin
FRONTIERS IN NEUROSCIENCE (2024)
Alejandro N. Rondón Ortiz,Lushuang Zhang,Peter E.A. Ash,Avik Basu,Sambhavi Puri,Sophie J.F. van der Spek, Zihan Wang,Luke Dorrian,Andrew Emili,Benjamin Wolozin
The Journal of biological chemistryno. 9 (2024): 107621-107621
Chelsea J. Webber, Caroline N. Murphy, Alejandro N. Rondon-Ortiz,Sophie J. F. van der Spek, Elena X. Kelly, Noah M. Lampl,Giulio Chiesa,Ahmad S. Khalil,Andrew Emili,Benjamin Wolozin
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Advanced Chemical Microscopy for Life Science and Translational Medicine 2023 (2023)
Research Square (Research Square) (2023)
Pijush Chakraborty,Alain Ibáñez de Opakua, Jeffrey A. Purslow,Simon A. Fromm, Debdeep Chatterjee,Milan Zachrdla,Sambhavi Puri,Benjamin Wolozin,Markus Zweckstetter
biorxiv(2023)
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作者统计
#Papers: 276
#Citation: 23436
H-Index: 70
G-Index: 152
Sociability: 7
Diversity: 0
Activity: 1
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