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Research in the Sullivan Lab involves studying how chromosomes are organized into inherited chromatin domains and understanding mechanisms of formation and behavior of chromosome abnormalities that are associated with birth defects, reproductive abnormalities, and cancer.
One focus of the lab’s research is the centromere, a specialized chromosomal site involved in chromosome architecture and movement, kinetochore function, heterochromatin assembly, and sister chromatid cohesion. Our experiments have uncovered a unique type of chromatin (CEN chromatin) formed exclusively at the centromere by replacement of core histone H3 by the centromeric histone variant CENP-A. Using high-resolution fluorescence microscopy and optical mapping, we have shown that centromeric chromatin (CEN chromatin) contains interspersed subdomains of CENP-A and H3 nucleosomes. Since CEN chromatin also contains H3, we are interested in determining if modifications of core histones functionally distinguish centromeres from other regions of the genome.
One focus of the lab’s research is the centromere, a specialized chromosomal site involved in chromosome architecture and movement, kinetochore function, heterochromatin assembly, and sister chromatid cohesion. Our experiments have uncovered a unique type of chromatin (CEN chromatin) formed exclusively at the centromere by replacement of core histone H3 by the centromeric histone variant CENP-A. Using high-resolution fluorescence microscopy and optical mapping, we have shown that centromeric chromatin (CEN chromatin) contains interspersed subdomains of CENP-A and H3 nucleosomes. Since CEN chromatin also contains H3, we are interested in determining if modifications of core histones functionally distinguish centromeres from other regions of the genome.
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Bala S. Balakumaran,Alessandro Porrello,David S. Hsu, Wayne Glover, Adam Foye, Janet Y. Leung,Beth A. Sullivan,William C. Hahn,Massimo Loda,Phillip G. Febbo
crossref(2023)
Bala S. Balakumaran,Alessandro Porrello,David S. Hsu, Wayne Glover, Adam Foye, Janet Y. Leung,Beth A. Sullivan,William C. Hahn,Massimo Loda,Phillip G. Febbo
crossref(2023)
Bala S. Balakumaran,Alessandro Porrello,David S. Hsu, Wayne Glover, Adam Foye, Janet Y. Leung,Beth A. Sullivan,William C. Hahn,Massimo Loda,Phillip G. Febbo
crossref(2023)
SCIENCEno. 6588 (2021): 44-+
Encyclopedia of Biological Chemistry IIIpp.496-502, (2021)
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