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Bio
Work is currently underway in Chait’s lab to develop novel spectrometry instrumentation for ultrasensitive, rapid, and comprehensive characterization of proteomes, the entire complement of proteins within cells, at the level of single cells. Existing methods of tandem mass spectrometry involve isolating the ion of interest, fragmenting it, and then measuring the mass spectrum of the fragments. However, much of this process is inherently extremely wasteful, since, at any given time, all ion species except for the one that is specifically isolated are thrown away. The Chait lab is investigating new strategies for overcoming this inefficiency using newly devised instrumentation for carrying out massively parallel mass spectrometry.
Research Interests
Papers共 653 篇Author StatisticsCo-AuthorSimilar Experts
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Thomas C. McLean, Francisco Balaguer-Pérez,Joshua Chandanani,Christopher M. Thomas,Clara Aicart-Ramos, Sophia Burick,Paul Dominic B. Olinares,Giulia Gobbato,Julia E. A. Mundy,Brian T. Chait,David M. Lawson,Seth A. Darst,
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
crossref(2024)
crossref(2024)
Nucleus (Austin, Tex.)no. 1 (2024): 2310452-2310452
biorxiv(2023)
Zenodo (CERN European Organization for Nuclear Research) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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