基本信息
浏览量:6
职业迁徙
个人简介
Research interests
Chromosome integrity
Chromosomes in eukaryotes control their environment to ensure that genomic integrity is maximised. We are interested in understanding mechanisms of genomic integrity operating at the molecular and cellular level, and determining the consequences when they fail.
Future directions
A key focus concerns the functional characterisation of the DNA /RNA helicase Upf1 which acts pleiotropically to regulate NMD, HD and telomere integrity. We have identified a novel NMD inhibitor which, importantly, does not affect histone mRNA regulation or telomere integrity.
We aim to utilise our expertise in genomic integrity and mass spectrometry to identify the target of this inhibitor as a potential therapeutic strategy for the treatment of nonsense mutation-associated disease.
研究兴趣
论文共 51 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Moleculesno. 9 (2024)
Felicity F Noakes,Kirsty L Smitten, Laura E C Maple,Jorge Bernardino de la Serna,Craig C Robertson, Dylan Pritchard,Simon D Fairbanks,Julia A Weinstein,Carl G W Smythe, Jim A Thomas
Moleculesno. 9 (2024): 2113
HELIYONno. 11 (2023): e22365-e22365
M. Isabel Acuña,Ana R. Rubio,Marta Martínez-Alonso,Natalia Busto,Ana María Rodríguez, Nerea Davila-Ferreira,Carl Smythe,Gustavo Espino,Begoña García,Fernando Domínguez
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn